Pulmonary hypertension and respiratory function in parenchyma sparing surgical treatment of lung cancer

A A Kirshin; V M Napol'skikh

doi:10.17816/KMJ2018-876

Kazan medical journal ›› 2018, Vol. 99 ›› Issue (6) :876 -879. DOI: 10.17816/KMJ2018-876

Theoretical and clinical medicine

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Pulmonary hypertension and respiratory function in parenchyma sparing surgical treatment of lung cancer

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Abstract

Aim. To assess the effect of pulmonary hypertension on respiratory function in lung cancer surgery.

Methods. 92 patients diagnosed with non-small cell lung cancer, among them 69 men (75 %) and 23 women (25 %), were operated on with different variants of angioplastic lobectomy (APL), the average age was 57.8 ± 6.7 years. 91 patients underwent pulmonectomy (PE), among them 87 men (95.6 %) and 4 women (4.4 %), the average age was 59 ± 8.8 years.

Results. One year after angioplastic lobectomy FEV1 decreased by 0.69 liters (27 %), vital capacity decreased by 1.17 liters (32.9 %), FVC (the difference between the volumes of lungs at the beginning and at the end of forced expiration) reduced by 0.64 liters (20.5 %). After removal of the lung, dynamics of the decrease of similar indicators was 1.02 (42 %); 1.53 (43.8 %); 1.24 (40.3 %) liter respectively. The presence of a negative relationship between PA/A (pulmonary artery/aorta) and FEV1 was revealed. Thus, in the group of angioplastic lobectomy without initial pulmonary hypertension (PA/A less than 1) it was found that r = -0.42 (p < 0.01), with pulmonary hypertension (PA/A 1 or more) r = -0.4 (p < 0.01). In the group of pulmonectomy without initial pulmonary hypertension, the correlation index was -0.38 (p < 0.01), with initial pulmonary hypertension r = -0.33 (p < 0.01).

Conclusion. The analysis of the functional parameters of pulmonary system after the surgery revealed statistically significant advantage of organ-saving treatment, as well as negative correlation between pulmonary hypertension and respiratory function.

Keywords

lung cancer / pulmonary artery resection / pulmonary hypertension / respiratory function

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A A Kirshin, V M Napol'skikh. Pulmonary hypertension and respiratory function in parenchyma sparing surgical treatment of lung cancer. Kazan medical journal, 2018, 99(6): 876-879 DOI:10.17816/KMJ2018-876

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