Prediction of adult-onset bronchial asthma in patients with metabolic syndrom in actual practice

Abstract

Aim. Adult asthma diagnosis optimization for patients with metabolic syndrome using prognostic methods.

Methods. The study included 46 patients with metabolic syndrome. Out of them, at the time of the study 31 subjects suffered from adult-onset bronchial asthma. All participants of the study had a history and complaints collected, and a clinical examination performed. Spirometry was used to assess the severity of bronchial obstruction syndrome. To assess the severity of metabolic syndrome components, glucose and fasting insulin concentrations, and lipid profile were determined, the homeostasis index of insulin resistance was calculated. Also in all participants the concentrations of leptin and endothelin-1 in the serum were determined.

Results. Risk of adult-onset bronchial asthma in a typical patient with metabolic syndrome spikes with maximal blood pressure higher than 154/90 mm Hg, and immunoglobulin E and leptin level higher than 33 ME/ml and 3.7 ng/ml, respectively. Blood pressure level affects adult-onset bronchial asthma pathogenesis only in combination with other metabolic syndrome components. Immunoglobulin E-mediated reactions play an important role in the pathogenesis of adult-onset bronchial asthma, and leptin acts as a regulator of pathogenetic mechanism.

Conclusion. Development of adult-onset bronchial asthma in patients with metabolic syndrome may be predicted on the basis of various variables; according to our data, those variables include maximum systolic and diastolic blood pressure levels, and levels of immunoglobulin E and leptin.

Keywords

adult-onset bronchial asthma / metabolic syndrome / logistic regression / arterial hypertension / immunoglobulin E / leptin

RIGHTS & PERMISSIONS

Kosmynina M.A., Kupaev V.I.