Features of inflammation course in rats with experimental hyper- and hypothyroidism

Abstract

Aim. To mark out the features of inflammatory reactions alterations in rats with experimental thyroid gland dysfunction. Methods. Experimental hypothyroidism was modeled by daily thiamazole intake in 50 Wistar rats. Hyperthyroidism was modeled with daily lyothyronine intake in 50 Wistar rats. An inflammation was modeled by artificial gum injury. 10 intact rats were examined as a control group. Results. Experimental hypothyroidism was accompanied by leukocyte biocidity decrease both in blood and periodontium, decreased lysosomal enzymes activity and antioxidant activity, and accumulation of lipid peroxidation products. Periodontal suppurations at experimental inflammation were 1.5 more frequent in rats with hypothyroidism compared to controls due to decreased leukocyte biocidity and antioxidant activity. Experimental hyperthyroidism was associated with increased biocidity and decreased functional reserves in phagocytes both in blood and periodontium, as well as antioxidant activity decrease and lipid peroxidation intensification. Changes of tumor necrosis factor alpha blood concentration both in hypothyroidism and hyperthyroidism corresponded with changes of phagocyte biocidity. The rate of periodontal suppuration in rats with hyperthyroidism was twice lower on the day 7 compared to controls due to high leukocyte and macrophage biocidity. Conclusion. Experimental hypothyroidism was accompanied by intensifying of lipid peroxidation and decreased tissue reparation ability; experimental hyperthyroidism was associated with increased biocidity and decreased functional reserves in phagocytes, and less evident decrease of compensatory abilities of antioxidant system lipid peroxidation intensification compared to hypothyroidism.

Keywords

hypothyroidism / hyperthyroidism / leukocyte and macrophage biocidity

References

[1] Маянский Д.Н. Лекции по клинической патологии. Руководство для врачей. - М.: ГЭТАР-Медиа, 2008. - 463 с.

[2] Barrett A.J. Lysosomes, a laboratory handbook. - Amsterdam-London, 1972. - P. 46-149.

[3] Kagiw I., Mirfit K.C. Determination of blood glutathione // Biochem. J. - 1960. - Vol. 74,N 1. - P. 203-208.

[4] Klein J.R. Physiological relevance of thyroid stimulating hormone and thyroid stimulating hormone receptor in tissues other than the thyroid // Autoimmunity. - 2003. - Vol. 36,N 6-7. - P. 417-421.

[5] Webster J.I., Tonelli L., Sternberg E.M. Neuroendocrine regulation of immunity //Annu Rev. Immunol. - 2002. - Vol. 20. - P. 125-163.

RIGHTS & PERMISSIONS

Mayanskaya N.N., Rimar S.S., Mayanskaya S.D.