The role of genetic polymorphism in the formation of atherosclerosis in the vessels of lower extremities

Abstract

Personalized medicine involves the use of methods of genomics and proteomics by physicians for early diagnosis, prediction of the nature of the disease course and the choice of medicines and their doses based on personalized characteristics of the individual patient. Advances in the study of the human genome make it possible to reveal the interrelation between the individual mutations in the human genes (polymorphisms) and predisposition to certain diseases. Currently there are more than 10 million single-nucleotide polymorphisms in the human genome, however their biological role remains poorly understood. On the basis of a literature search of electronic full-text and abstract-only versions of articles, which was conducted in the PUBMED, OMIM and GENE databases, collected was the information on genetic predisposition to systemic atherosclerosis. The review is dedicated to polymorphisms of the major genes that play a role in the pathophysiology of atherosclerosis of the lower extremities.

Keywords

gene polymorphism / pathophysiology of systemic atherosclerosis / ischemic heart disease

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RIGHTS & PERMISSIONS

Katina M.N., Gayfullina R.F., Valiullin V.V., Rizvanov A.A., Khamitov R.F., Rizvanova F.F.