Prospects for using agonists and antagonists of P2 receptors in clinical ophthalmology

Abstract

This literature review focuses on the role of purinergic P2-receptors in the physiology and pathophysiology of the eye, as well as on the possibilities of pharmacologic stimulation of these receptors. The most important studies from the clinical point of view on the involvement of purinergic neuronal transmission in the physiological processes have been analyzed, ranging from normal embryogenesis to cell apoptosis in age-related degenerative diseases of the eye. Data on the effect of agonists and antagonists of P2 receptors on corneal wound healing, lacrimal fluid production, regulation of intraocular pressure, neurotransmission, proliferation of glial tissue in the retina has been presented along with data on the possibilities of modulating these processes by using potential drugs acting via P2 receptors.

Keywords

P2 receptors / agonists of P2 receptors / eye / intraocular pressure / diseases of the retina

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RIGHTS & PERMISSIONS

Ziganshina A.P., Ziganshin B.A., Samoilov A.N., Ziganshin A.U.