The state of the oxidation-reduction system in patients with primary open angle glaucoma

I R Gazizova

doi:10.17816/KMJ1874

Kazan medical journal ›› 2012, Vol. 93 ›› Issue (3) : 488 -490. DOI: 10.17816/KMJ1874

Clinical medicine

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The state of the oxidation-reduction system in patients with primary open angle glaucoma

I R Gazizova

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Abstract

Aim. To study the state of the oxidation-reduction system in patients with primary open-angle glaucoma. Methods. Conducted were biochemical studies of the state of the oxidation-reduction system in 30 patients with primary open-angle glaucoma. The level of lipid peroxidation of cell membranes was determined in blood serum by the method of accumulation of malondialdehyde based on its interaction with thiobarbituric acid. The state of the antioxidant system was assessed according to the activity of superoxide dismutase, catalase, glutathione reductase and the content of thiol disulfide groups in the blood. The concentration of lactate in the blood serum was determined using an automated analyzer. Results. In patients with a chronic course of glaucoma elevated levels of oxidized thiol groups of proteins, increased activity of antioxidant enzymes, activation of lipid peroxidation processes, increased lactate content have been identified. Conclusion. Changes in the oxidation-reduction system in patients with primary open-angle glaucoma may be a sign of mitochondrial dysfunction.

Keywords

primary open-angle glaucoma / thiol groups of proteins / antioxidant enzymes / lipid peroxidation

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I R Gazizova. The state of the oxidation-reduction system in patients with primary open angle glaucoma. Kazan medical journal, 2012, 93(3): 488-490 DOI:10.17816/KMJ1874

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[1]	Алексеев В.Н., Мартынова Е.Б., Малеванная О.А. и др. Значение митохондриальной патологии в медицине и в офтальмологии // Глаукома: теория и практика. Рос. глаукомная школа: Сб. научн. тр. - СПб.: Человек и его здоровье, 2011. - С. 3-5.

[2]	Волков В.В. Глаукома при псевдонормальном давлении: Руководство для врачей. - М.: Медицина, 2001. - 352 с.

[3]	Нестеров А.П. Первичная открытоугольная глаукома: патогенез и принципы лечения // Клин. офтальмология. - 2000. - №1. - С. 4-5.

[4]	Browne S.E., Beal M.F. The energetics of Huntington’s disease // Neurochem. Res. - 2004. - Vol. 29. - Р. 531-546.

[5]	Calandrella N., Scarsella G., Pescosolido N. et al. Degenerative and apoptotic events at retinal and optic nerve level after experimental induction of ocular hypertension // Mol. Cell. Biochem. - 2007. - Vol. 301 - Р. 155-163.

[6]	Carelli V., Ross-Cisneros F.N., Sadun A.A. Mitochondrial dysfunction as a cause of optic neuropathies // Prog. Retin. Eye Res. - 2004. - Vol. 23. - Р. 53-89.

[7]	Danesh-Meyer H.V. Neuroprotection in glaucoma: recent and future directions // Curr. Opin. Ophthal. - 2011. - Vol. 22. - P. 78-86.

[8]	George Y.X., Van Bergen N.J., Trounce I.A. et al. Mitochondrial Dysfunction and Glaucoma // J. Glaucoma. - 2009. - Vol. 18. - Р. 93-100.

[9]	Kujoth G.C., Hiona A., Pugh T.D. et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging // Science. - 2005. - Vol. 309. - Р. 481-484.