Clinical features of bacterial dysentery caused by shigella flexneri and associated with severe neurologic disease
S V Khaliullina , V A Anokhin , Kh S Khaertynov , Yu R Urmancheeva , K V Sushnikov , E Yu Alatyrev , A N Valiullina , E A Khasanova
Kazan medical journal ›› 2014, Vol. 95 ›› Issue (4) : 534 -537.
Clinical features of bacterial dysentery caused by shigella flexneri and associated with severe neurologic disease
Aim. To assess clinical and epidemiological features of bacterial dysentery caused by Shigella Flexneri 2а in children with severe neurologic comorbidities. Methods. 27 case histories of children with the clinical picture of shigellosis were analyzed. All patients were admitted to the pediatric ward of the hospital of infectious diseases from specialized neuropsychiatric care home in October-November 2013. Results. Clinical picture of bacterial dysentery in examined children was classic. 22 out of 27 children (81.5%, CI 66.9-96.1) had mild disease, 3 (11.1%, CI -0.7-22.9) - moderate, 2 (7.4%, CI -2.5-17.3) - severe form of the disease. In majority of cases, intestinal involvement was manifesting as enterocolitis - in 20 out of 27 patients (74.1%, CI 57.6-90.6). In 3 patients (11.1%, CI -0.7-22.9), shigellosis was manifesting as gastroenterocolitis. In 4 cases (14.8%, CI 1.4-28.2) clinical signs of hemorrhagic colitis were observed. Severe dehydration (2nd and 3rd degree) was registered in 4 out of 27 patients, (14.8%, CI 1.4-28.2), moderate - in 2 (7.4%, CI -2.5-17.3). In 4 out of those 6 patients (66.7%, CI 29-104.4) dehydration was isotonic, in 2 (33.3%, CI 0.4-75) - hypotonic. Conclusion. The infectious disease did not influence the clinical course of concomitant neurologic disorder and did not lead to development of neurologic complications in the admitted patients. In most of the cases shigellosis was mild, and patient’s condition was mostly determined by a concomitant disease.
shigellosis / children / neurologic complications / severe comorbidities
| [1] |
Покровский В.И., Акимкин В.Г., Брико Н.И. и др. Национальная концепция профилактики инфекций, связанных с оказанием медицинской помощи, и информационный материал по её положениям. - Н. Новгород: Ремедиум Приволжье, 2012. - 84 с. |
| [2] |
Постановление Главного государственного санитарного врача Российской Федерации от 19 марта 2010 г. №21 «О профилактике острых кишечных инфекций» // Рос. газета. - 2010 (30 апреля). - С. 21. |
| [3] |
Халиуллина С.В., Анохин В.А., Гутор И.А., Хасанова Г.Р. Этиологическая структура острых инфекционных диарей у детей и взрослых // Практ. мед. - 2012. - №1 (56). - С. 13-15. |
| [4] |
Avital A., Maayan C., Goitein K.J. Incidence of convulsions and encephalopathy in childhood Shigella infections. Survey of 117 hospitalized patients // Clin. Pediatr. (Phila). - 1982. - Vol. 21, N 11. - P. 645-648. |
| [5] |
Ashkenazi S. Shigella infections in children: new insights // Semin. Pediatr. Infect. Dis. - 2004. - Vol. 15, N 4. - P. 246-252. |
| [6] |
Ashkenazi S., Dinari G., Zevulunov A. et al. Convulsions in childhood shigellosis. Clinical and laboratory features in 153 children // Am. J. Dis. Child. - 1987. - Vol. 141, N 2. - P. 208-210. |
| [7] |
Belnicoff S.A., Grassi D. Encephalopathy in an adult with Shigella // Medicina (B Aires). - 1991. - Vol. 51, N 1. - P. 56-58. |
| [8] |
Yuhas Y., Shulman L., Weizman A. et al. Involvement of tumor necrosis factor alpha and interleukin-1beta in enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae // Infect. Immun. - 1999. - Vol. 67, N 3. - P. 1455-1460. |
| [9] |
Wasif A.K., Ujjwal D., Mohammed A.S. et al. Сentral nervous system manifestations of childhood Shigellosis: prevalence, risk factors, and outcome // Pediatrics. - 1999. - Vol. 103. - P. 18. |
Khaliullina S.V., Anokhin V.A., Khaertynov K.S., Urmancheeva Y.R., Sushnikov K.V., Alatyrev E.Y., Valiullina A.N., Khasanova E.A.
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