Cardiovascular comorbidity and free radical mediated processes imbalance in patients with acute stroke

Abstract

Aim. To study the free radical imbalance in patients with acute cerebrovascular disease and cardiovascular comorbidity and to determine its prognostic value. Methods. 141 patients with acute cerebrovascular disease of different severity aged 28-94 years (mean age 65.48±13.44 years) with various concomitant conditions were included. Ischemic stroke was diagnosed in 87 (61.7%), haemorragic stroke - in 35 (24.8%), transient ischemic attack - in 19 (13.5%) patients. Free radical processes in blood serum were examined repeatedly based on oxidative and peroxidative markers of oxidative stress. Results. Among the observed patients, 25.5% had one or no cardiovascular diseases, 24.8% had two, 27.0% had three and 22.7% had four and over. The increase in free radical imbalance was related to the increase in concomitant conditions number - there was a decrease of leukocyte chemiluminescence basal intensity by 1,76 times in patients with 4 cardiovascular diseases and above compared to 1 cardiovascular disease; increase of zymosan-stimulated leukocyte chemiluminescence intensity by 1.44 times; depression of antiperoxide activity of secondary serum by 1.36 times and increase of malondialdehyde by 1.5 times (р <0.05). Unfavorable outcome was observed in 9.7% of patients with 1 cardiovascular disease, which is 2.66 times lower compared to patients with acute cerebrovascular disease and 2 cardiovascular diseases (р <0.05), 3.55 times lower compared to patients with 3 cardiovascular diseases (р <0.05) and 2.67 times lower compared to patients with ≥4 cardiovascular diseases (р <0.05). Conclusion. Indices of free radical processes may be used as additional markers for prognosis and functional outcome evaluation of acute cerebrovascular disease with concomitant cardiovascular diseases.

Keywords

stroke / cardiovascular comorbidity / oxidative stress / free radicals

RIGHTS & PERMISSIONS

Orlova A.S., Men’shova N.I., Rumjanceva S.A., Silina E.V., Stupin V.A., Orlov V.A., Sinel’nikova T.G., Bolevich S.B.