Arterial stiffness of peripheral vasculature in patients with chronic obstructive pulmonary disease and its association with arterial hypertension

V V Gajnitdinova; A B Bakirov; E Kh Akhmetzyanova; N F Berdikaeva; V B Zakirova

doi:10.17816/KMJ1795

Kazan medical journal ›› 2013, Vol. 94 ›› Issue (6) : 808 -812. DOI: 10.17816/KMJ1795

Theoretical and clinical medicine

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Arterial stiffness of peripheral vasculature in patients with chronic obstructive pulmonary disease and its association with arterial hypertension

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Abstract

Aim. To study the structural and functional state of vascular wall, arterial stiffness of large peripheral arteries (common carotid arteries, renal arteries) in patients with severe chronic obstructive pulmonary disease and its association with arterial hypertension. Methods. The study included 67 patients of working age, mainly males, having chronic obstructive pulmonary disease. Among them, 52 patients had severe chronic obstructive pulmonary disease (defined by GOLD III, 2011), 15 had concomitant arterial hypertension of I and II stage. Structural and functional status of common carotid arteries, renal arteries was assessed by measurement of intima-media thickness, arterial stiffness indexes were calculated. Arterial elasticity indices: arterial compliance, elastic index, Young’s elastic modulus were calculated based on the results of ultrasonography of main arterial wall parameters (diameter, arterial wall thickness) and blood pressure measurement. Results. A decrease in common carotid arteries and renal arteries wall elasticity was revealed in patients with chronic obstructive pulmonary disease. Increase of stiffness index in patients with severe chronic obstructive pulmonary disease associated with arterial hypertension, marking the decreased arterial wall elasticity, was registered both in common carotid arteries and renal arteries. Conclusion. In common carotid arteries vascular wall thickness contribute the most in vascular wall stiffness increase, compared to altered hemodynamics in renal arteries. Development of arterial hypertension in these patients is a predicting factor for further large vessel remodeling associated with hypoxia.

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chronic obstructive pulmonary disease / arterial hypertension / arterial stiffness / hypoxia

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V V Gajnitdinova, A B Bakirov, E Kh Akhmetzyanova, N F Berdikaeva, V B Zakirova. Arterial stiffness of peripheral vasculature in patients with chronic obstructive pulmonary disease and its association with arterial hypertension. Kazan medical journal, 2013, 94(6): 808-812 DOI:10.17816/KMJ1795

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References

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[1]	Аксёнов Т.А., Горбунов В.В., Пахоменко Ю.В. и др. Суточное мониторирование центрального аортального давления и показателей артериальной ригидности при сочетании гипертонической болезни с хронической обструктивной болезнью лёгких // ЭНИ Забайкал. вестн. - 2012. - №2. - С. 9-16.

[2]	Жирнова О.А., Берестень Н.Ф., Пестовская О.Р., Богданова Е.Я. Неинвазивная диагностика нарушения эластических свойств артериальных сосудов // Ангиология. Электрон. ж. - 2011. - №1. - С. 18-25.

[3]	Кочкина М.С., Затейщиков Д.А., Сидоренко Б.А. Измерение жёсткости артерий и её клиническое значение // Кардиология. - 2005. - №1. - С. 63-71.

[4]	Макарова М.А., Авдеев С.Н. Артериальная ригидность и эндотелиальная дисфункция у больных хронической обструктивной болезнью лёгких // Пульмонология. - 2011. - №4. - С. 109-117.

[5]	Отиева Э.Н., Клинкова Е.В., Гарбузова О.Г. и др. Артериальная ригидность - маркёр развития сердечно-сосудистых заболеваний // Клин. мед. - 2012. - №1. - С. 4-11.

[6]	Ратова Л.Г., Зыков К.А., Долгушева Ю.А. и др. Артериальная гипертония и бронхообструктивная патология - особенности клинической картины // Системн. гипертенз. - 2012. - №1. - С. 54-58.

[7]	Boussuges A., Rossi P., Gouitaa M., Nussbaum E. Alterations in the peripheral circulation in COPD patients // Clin. Physiol. Funct. Imag. - 2007. - Vol. 27. - P. 284-290.

[8]	Enright P.L., Kronmal R.A., Smith V.E. et al. Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy. The Cardiovascular Health Study // Chest. - 1995. - Vol. 107. - P. 28-35.

[9]	Fabbri L.M., Luppi F., Beghe B. et al. Complex cronic comorbidities of COPD // Eur. Respir. J. - 2008. - Vol. 31. - P. 204-212.

[10]	Maclay J.D., McAllister D.A., Mills N.L. et al. Vascular dysfunction in chronic obstructive pulmonary disease 2009 // Am. J. Respir. Crit. Care Med. - 2009. - Vol. 180. - P. 513-520.

[11]	Sabit R., Bolton C.E., Edwards P.H. et al. Arterial stiffness and osteoporosis in chronic obstructive pulmonary diseas // Am. J. Respir. Crit. Care Med. - 2007. - Vol. 175. - P. 1259-1265.

[12]	Thomas M., Taylor R. Assessing inflammary phenotypes and improving the cost-effectiveness of asthma and COPD care in the community // Prim. Care Raspir. J. - 2011. - Vol. 20, N 4. - P. 349-350.