Pathogenetic treatment of the patient with splenic marginal zone lymphoma complicated by Evans syndrome
N A Romanenko , S S Bessmeltsev , K M Abdulkadyrov
Kazan medical journal ›› 2012, Vol. 93 ›› Issue (5) : 843 -846.
Pathogenetic treatment of the patient with splenic marginal zone lymphoma complicated by Evans syndrome
A case report of a patients with splenic marginal zone lymphoma, in whom clinical remission was initially achieved by 5 continuous courses of combined treatment with fludarabine 25 mg/m2 and cyclophosphamide 350 mg/m2 at days 1-3. Nevertheless, 6 months after patient developed a clinical picture of Evans syndrome, characterized by severe hemolytic anemia, thrombocytopenia and neutropenia. Corticosteroid treatment accompanied by blood transfusion was initiated, the effect was marginal and short-lasting. Switch to rituximab monotherapy allowed to archieve complete clinical and hematological remission with full blood count parameters reversal.
splenic marginal zone lymphoma / anemia / thrombocytopenia / red blood cells transfusion / erythropoietin alpha / Evans syndrome / rituximab / CD20 antibodies
Romanenko N.A., Bessmeltsev S.S., Abdulkadyrov K.M.
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