Influence of triphenyltetradecylphosphonium bromide on the Na+-Li+- countertransport rate in the erythrocyte membrane in patients with genetically different permeability of cell membranes to sodium

O V Orlova , V N Oslopov , S A Sidullina

Kazan medical journal ›› 2012, Vol. 93 ›› Issue (5) : 789 -791.

PDF
Kazan medical journal ›› 2012, Vol. 93 ›› Issue (5) : 789 -791. DOI: 10.17816/KMJ1711
Experimental medicine
research-article

Influence of triphenyltetradecylphosphonium bromide on the Na+-Li+- countertransport rate in the erythrocyte membrane in patients with genetically different permeability of cell membranes to sodium

Author information +
History +
PDF

Abstract

Aim. To study the influence of triphenyltetradecylphosphonium bromide [(PPh)3P+C14H29] Br- on the cell membranes permeability to Na+ by determining the rate of Na+-Li+-counter transport in erythrocyte membrane depending on it’s variable initial condition. Methods. Blood samples of 10 healthy volunteers with different Na+-Li+-counter transport rate distribution in erythrocyte membrane were analyzed: I quartile (5 subjects) - low permeability, III quartile (5 subjects) - moderately high permeability. Results. Na+-Li+-counter transport rate change in erythrocyte membrane under the influence of triphenyltetradecylphosphonium bromide depends on genetically determined initial membrane permeability. In subjects belonging to III quartile of Na+-Li+-counter transport the initial membrane permeability is high, and after administration of 0.001 and 0.005 μM concentrations of [(PPh)3P+C14H29] Br- membrane permeability to Na+ increased. In subjects belonging to I quartile of Na+-Li+-counter transport (low initial permeability) [(PPh)3P+C14H29] Br- did not alter membrane permeability to Na+. Conclusion. Triphenyltetradecylphosphonium bromide increases erythrocyte membrane permeability to Na+ in subjects belonging to III quartile of Na+-Li+-counter transport and dose not influence subjects belonging to I quartile of Na+-Li+-counter transport.

Keywords

erythrocyte membrane permeability / triphenyltetradecylphosphonium bromide / Na+-Li+-counter transport

Cite this article

Download citation ▾
O V Orlova, V N Oslopov, S A Sidullina. Influence of triphenyltetradecylphosphonium bromide on the Na+-Li+- countertransport rate in the erythrocyte membrane in patients with genetically different permeability of cell membranes to sodium. Kazan medical journal, 2012, 93(5): 789-791 DOI:10.17816/KMJ1711

登录浏览全文

4963

注册一个新账户 忘记密码

References

RIGHTS & PERMISSIONS

Orlova O.V., Oslopov V.N., Sidullina S.A.

AI Summary AI Mindmap
PDF

60

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/