Prediction of atrial fibrillation according to levels of serum markers of inflammation during arterial hypertension

L M Vasilets; A V Agafonov; O V Khlynova; E A Ratanova; N E Grigoriadi; A A Krivaya; K V Trenogina

doi:10.17816/KMJ1561

Kazan medical journal ›› 2012, Vol. 93 ›› Issue (4) : 642 -646. DOI: 10.17816/KMJ1561

Theoretical and clinical medicine

research-article

Prediction of atrial fibrillation according to levels of serum markers of inflammation during arterial hypertension

Author information +

History +

PDF

Abstract

Aim. To study the parameters of inflammation during atrial fibrillation in patients with arterial hypertension and to determine the possibility of their predictive significance in relation to development of the arrhythmia. Methods. Examined were 97 individuals with arterial hypertension, mean age 50.53±8.10 years. Formed were two groups: patients with arterial hypertension without the arrhythmia and patients with atrial fibrillation on the background of arterial hypertension. Among the examined patients with atrial fibrillation revealed were patients with persistent or recurrent persistent forms of atrial fibrillation, the latter were examined both without and during the paroxysm of arrhythmia. The comparison group was comprised of 21 practically healthy individuals. In all patients determined was the content of C-reactive protein, tumor necrosis factor-alpha, and fibrinogen. Results. Paroxysms of atrial fibrillation were accompanied by a significant increase in the concentration of the tumor necrosis factor-alpha. The level of C-reactive protein had an inverse correlation with the severity of atrial fibrillation, that is, in cases of persistent atrial fibrillation it was lower than in cases of paroxysmal forms of atrial fibrillation, as well as in patients with arterial hypertension without the arrhythmia. Conclusion. Variation in the levels of inflammation markers is an independent predictor of atrial fibrillation in patients with arterial hypertension.

Keywords

atrial fibrillation / arterial hypertension / C-reactive protein / tumor necrosis factor-alpha / fibrinogen

Cite this article

Download citation ▾

L M Vasilets, A V Agafonov, O V Khlynova, E A Ratanova, N E Grigoriadi, A A Krivaya, K V Trenogina. Prediction of atrial fibrillation according to levels of serum markers of inflammation during arterial hypertension. Kazan medical journal, 2012, 93(4): 642-646 DOI:10.17816/KMJ1561

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Маркин С.С., Ольбинская Л.И., Игнатенко С.Б. Фактор некроза опухолей в плазме крови и морфофункциональные параметры сердца у больных с хронической сердечной недостаточностью, осложнившей течение ишемической болезни сердца, динамика под влиянием лечения // Терап. арх. - 2003. - №2. - С. 54-58.

[2]	Насонов Е.Л., Панюкова Е.В., Александрова Е.Н. С-реактивный белок - маркёр воспаления при атеросклерозе (новые данные) // Кардиология. - 2002. - №7. - С. 53-62.

[3]	Термосесов С.А., Вотчал Ф.Б., Костылёва О.В. и др. Немедикаментозные методы лечения фибрилляции предсердий // Сердеч. недост. - 2001. - Т. 2, №5. - С. 231-234.

[4]	Bradham W.S., Bozkurt B., Gunasinghe H. et al. Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective // Cardiovasc. Res. - 2002. - Vol. 53. - P. 822-830.

[5]	Chung M.K., Martin D.O., Sprecher D. et al. C-reactive protein elevation in patients with atrial arrhythmias. Inflammatory mechanisms and persistence of atrial fibrillation // Circulation. - 2001. - Vol. 104. - P. 2886.

[6]	Deng Hai, Xue Yu-mei, Zhan Xian-zhang et al. Role of tumor necrosis factor-alpha in the pathogenesis of atrial fibrillation // Chin. Med. J. - 2011. - Vol. 124, N 13. - P. 1976-1982.

[7]	Dernellis J., Panaretou M. Effect of C-reactive protein reduction on paroxysmal atrial fibrillation // Amer. Heart J. - 2005. - Vol. 150. - P. 12-14.

[8]	Go A.S., Hylek E.M., Phillips K.A. et al. Prevalence of diagnosed atrial fibrillation in adults // JAMA. - 2001. - Vol. 285. - Р. 2370-2375.

[9]	Koening W., Sund M., Frohlich M. et al. C-reactive protein a sensitive marker of inflammation, predict future risk of coronary heart disease in initially healthy middle-aged men // Circulation. - 1999. - Vol. 99. - P. 237-242.

[10]	Naoyuki S., Naokazu H., Takashi H. et al. C-reactive protein and atrial fibrillation. Is inflammation a consequence or a cause of atrial fibrillation? // Jpn. Heart J. - 2004. - Vol. 45, N 3. - P. 441-445.

[11]

Peason T.A., Mensah G.A., Wayne A.R. et al. Markers of inflammation and cardiovascular disease. Application to clinical and public health practice. A statement for healthcare professionals from the centers for disease control and prevention and American Heart Association // Circulation. - 2003. - Vol. 107. - P. 499-511.

[12]	Rodney H. Falk atrial fibrillation // New Engl. J. Med. - 2001. - Vol. 344, N 14. - Р. 1067-1078.

[13]	Sun M., Chen M., Dawood F. et al. Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state // Circulation. - 2007. - Vol. 115, N 11. - P. 1398-1407.

[14]	Yeh E.T.H., Anderson H.V., Pasceri V., Willerson J.T. C-reactive protein. Linking inflammation to cardiovascular complications // Circulation. - 2001. - Vol. 104. - P. 974.