Tuberculin diagnostics in pulmonary tuberculosis combined with HIV-infection

E A Borodulina; N O Lebedeva; L V Povalyaeva; I IL Tsygancov; B E Borodulin

doi:10.17816/KMJ1546

Kazan medical journal ›› 2012, Vol. 93 ›› Issue (4) : 576 -579. DOI: 10.17816/KMJ1546

Theoretical and clinical medicine

research-article

Tuberculin diagnostics in pulmonary tuberculosis combined with HIV-infection

Author information +

History +

PDF

Abstract

Aim. To evaluate the sensitivity to tuberculin in patients with infiltrative pulmonary tuberculosis in combination with an infection, caused by the human immunodeficiency virus (HIV), using various different tests. Methods. Examined were patients with infiltrative pulmonary tuberculosis with HIV infection (134 patients, the main group) and without HIV infection (100 patients, control group). Tuberculin diagnostics included an intradermal Mantoux test with 2 tuberculin units, the skin prick test with a 100% solution of PPD-L and the intradermal test «Diaskintest». Results. In the main group, a positive reaction to the Mantoux test with 2 tuberculin units was reported significantly less frequently (56.0%) than in the comparison group (89.0%), the diagnostic value of the test decreased with a decrease in the number of CD4+ lymphocytes. The prick test was characterized by a complete correlation with the results of the Mantoux test, although having a number of advantages. The sensitivity of the «Diaskintest» in the main group was 48.3%, and in the control group - 84.6%, at the same time the sensitivity of the «Diaskintest» decreased to 17% in cases of pronounced immunodeficiency. Conclusion. The skin prick test can be used as a screening method for early detection of tuberculosis in HIV-infected individuals with CD4+ lymphocyte count of 300 cells in 1 ml or more with the aim of forming risk groups, followed by screening for tuberculosis.

Keywords

tuberculosis / HIV infection / tuberculin diagnostics / Mantoux test / prick test / «Diaskintest»

Cite this article

Download citation ▾

E A Borodulina, N O Lebedeva, L V Povalyaeva, I IL Tsygancov, B E Borodulin. Tuberculin diagnostics in pulmonary tuberculosis combined with HIV-infection. Kazan medical journal, 2012, 93(4): 576-579 DOI:10.17816/KMJ1546

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Бородулина Е.А., Бородулин Б.Е., Амосова Е.А. Сравнительная оценка кожных туберкулиновых проб // Туберк. и бол. лёгких. - 2010. - №8. - С. 18-22.

[2]	Бородулина Е.А., Бородулин Б.Е. Индивидуальная туберкулинодиагностика прик-тестом // Проблем. туберк. и бол. лёгких. - 2006. - №3. - С. 33-35.

[3]	Ерохин В.В., Корнилова З.Х., Алексеева Л.П. Особенности выявления, клинических проявлений и лечения туберкулёза у ВИЧ-инфицированных // Пробл. туб. - 2005. - №10. - С. 20-28.

[4]	Фролова О.П., Шинкарёва И.Г. Основные результаты статистического анализа по данным годовых отчётов за 2007 год по туберкулёзу и ВИЧ-инфекции в РФ и выполняемые мероприятия противотуберкулёзной помощи больным ВИЧ-инфекцией. - Бюллетень ВОЗ №5. - М., 2008. - С. 2-7.

[5]	Аdri M., Ehrlich R., Wood R. et al. Association between tuberculosis and HIV disease progression in a high tuberculosis prevalence area // J. Tuberc. Lung. - 2001. - Vol. 5. - P. 225-232.

[6]	Sonnenberg P., Glynn J., Fielding K. et al. How soon after infection with HIV does the risk of tuberculosis start to increase? A retrospective cohort study in South African gold miners // J. Infect. - 2005. - Vol. 191. - P. 150-158.