Association of blood level of inflammatory mediators and morphology of coronary artery stenosis in patients with stable angina

Abstract

Aim. To study the association of morphology of coronary artery disease and pentraxin-3, tumor necrosis factor α blood levels in patients with stable angina who undergo coronary artery bypass surgery. Methods. The study included 92 patients aged 44-73 years with stable angina of II-III functional class. The coronary artery disease type was classified by AHA/ACC criteria: type A - concentric stenosis with flat plague and plague length less than 10 mm, type B - eccentric stenosis or blunt-edged stenosis with moderate calcinosis or signs of mural trombosis, with length not exceeding 200 mm, type C - stenosis with plague length over 20 mm, plague ulceration, marked calcinosis, diffuse lesions, chronic coronary artery occlusion. Pentraxin-3, tumor necrosis factor α blood levels were measured by ELISA in all patients before the surgery, 8 and 24 hours after the surgery. Results. There was a relation found between the type of stenosis and pentraxin-3 and tumor necrosis factor α blood levels. In patients with С type stenosis, pentraxin-3 blood level was 4 times higher (p <0.001) 24 hours after the coronary artery bypass surgery compared to patients with A type stenosis, and by 1.8 and 1.3 times higher compared to patients with В1 and В2 stenosis type, accordingly. Conclusion. There was a close relation revealed between the morphology of coronary artery stenosis and pentraxin-3 and tumor necrosis factor α blood levels in patients with stable angina.

Keywords

atherosclerosis / coronary artery bypass surgery / inflammatory mediators

References

[1] Anderson J.L., Carlquist J.F., Muhlestein J.B. et al. Evaluation of C-reactive protein, an inflammatory marker, and infection serology as risk factors for coronary artery disease and myocardial infarction // Am. Coll. Cardiol. - 1998. - Vol. 32. - P. 35-41.

[2] Avanzas P., Arroyo-Espliguero R., Cosin-Sales J. et al. Markers of inflammation and multiple complex stenoses (pancoronary plaque vulnerability) in patients with non-ST segment elevation acute coronary syndromes // Heart. - 2004. - Vol. 90. - P. 847-852.

[3] Battistoni A., Rubattu S., Volpe M. Circulating biomarkers with preventive, diagnostic and prognostic implications in cardiovascular diseases // Intern. J. Cardiol. - 2011. - Vol. 157, N 2. - P. 160-168.

[4] Bonaterra G.A., Zügel S., Kinscherf R. Novel systemic cardiovascular disease biomarkers // Curr. Mol. Med. - 2010. - Vol. 10, N 2. - P. 180-205.

[5] Breviario F., D’Aniello E.M., Golay J. et al. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component // J. Biol. Chem. - 1992. - Vol. 267, N 31. - P. 22 190-22 197.

[6] Garlanda C., Bottazzi B., Bastone A. et al. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility // Ann. Rev. Immunol. - 2005. - Vol. 23. - P. 337-366.

[7] Haidari M., Javadi E., Sadeghi B. et al. Evaluation of C-reactive protein, a sensitive marker of inflammation, as a risk factor for stable coronary artery disease // Clin. Biochem. - 2001. - Vol. 33. - P. 309-315.

[8] Haverkate F., Thompson S.G., Pyke S.D. et al. Production of C-reactive protein and risk of coronary events in stable and unstable angina // Lancet. - 1997. - Vol. 349. - P. 462-466.

[9] Introna M., Vidal V. Alles, Castellano M. et al. Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites // Blood. - 1996. - Vol. 87, N 5. - P. 1862-1872.

[10] Lee G.W., Lee T.H., Vilcek J.T. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins // J. Immunol. - 1993. - Vol. 150, N 5. - P. 1804-1812.

[11] Libby. P., Ridker P.M., Hansson G.K. Inflammation in atherosclerosis. From pathophysiology to practice // J. Am. Coll. Cardiol. - 2009. - Vol. 54, N 23. - P. 2129-2138.

[12] Norata G.D., Garlanda C., Catapano A.L. The long pentraxin PTX3: a modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases // Trends Cardiovasc. Med. - 2010. - Vol. 20, N 2. - P. 35-40.

[13] Peri G., Introna M., Corradi D. et al. PTX3, a prototypical long pentraxin, is an early indicator of acutemyocardial infarction in humans // Circulation. - 2000. - Vol. 102, N 6. - P. 636-641.

[14] Ridker P.M., Buring J.E., Shih J. et al. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women // Circulation. - 1998. - Vol. 98. - P. 731-733.

[15] Seiji K., Satoshi I., Takeo Y. et al. Elevated levels of systemic pentraxin 3 are associated with thin-cap fibroatheroma in coronary culprit lesions assessment by optical coherence tomography and intravascular ultrasound // J. Am. Coll. Cardiol. Intv. - 2013. - Vol. 6, N 9. - P. 945-954.

RIGHTS & PERMISSIONS

Mahmudov R.M., Mammadov V.S., Mirzakhanova L.R.