Postcovid necrosis of the cranio-maxillofacial region

Abstract

The review article is devoted to one of the new topical problems in medicine — necrosis of the organs of the cranio-maxillofacial region in patients with coronavirus infection, which was first discussed at the end of 2020. Later, doctors of various specialties (otolaryngologists, ophthalmologists, maxillofacial surgeons, neurosurgeons, dentists) from many countries of the world met in their practice with inflammatory-necrotic lesions of the mucous membrane of the nasal cavity and paranasal sinuses, facial skeleton and skull, eyeball, brain. The article highlights the main points of view of scientists about the etiology and pathogenesis of the studied pathology. Summarized data from the largest studies on the epidemiology, risk factors, and symptoms of post-covid necrosis of the cranio-maxillofacial region are presented. The results of various methods for diagnosing this complication — multislice computed tomography, magnetic resonance imaging, angiography, are described in detail. Due to the fact that today the role of fungal flora is recognized as the leading one in the etiology of post-covid necrosis of the cranio-maxillofacial region, much attention is paid to cytological, microbiological and pathohistological research methods, which should be aimed at the search for mycelium. The main approaches to the treatment of patients with this pathology are formulated. The article highlights issues important for practical healthcare: interpretation of national clinical guidelines for coronavirus infection in terms of post-covid necrosis of the cranio-maxillofacial region, classification options according to the International Classification of Diseases of the 10th revision, the procedure for providing medical care to this category of patients, the economic consequences of the lack of active prevention methods of the presented complication in patients with COVID-19.

Keywords

COVID-19 / necrosis / sinusitis / jaw / mucormycosis / review

References

[1] Belyakov NA, Trofimova TN, Rassokhin VV, Rybakova MG, Vasiliev BB. Postcovid syndrome — polymorphism of disorders in a new coronavirus infection. HIV Infection and Immunosuppressive Disorders. 2021;13(4):7–20. (In Russ.) DOI: 10.22328/2077-9828-2021-13-4-7-20.

[2] Беляков Н.А., Трофимова Т.Н., Рассохин В.В., Рыбакова М.Г., Васильев В.Б. Постковидный синдром — полиморфизм нарушений при новой коронавирусной инфекции. ВИЧ-инфекция и иммуносупрессии. 2021;13(4):7–20. DOI: 10.22328/2077-9828-2021-13-4-7-20.

[3] Pogosova NV, Paleev FN, Ausheva AK, Kuchiev DT, Gaman SA, Veselova TN, Belkind MB, Sokolova OYu, Zhetisheva RA, Ternovoy SK, Boytsov SA. Sequelae of COVID-19 at long-term follow-up after hospitalization. Rational Pharmacotherapy in Cardiology. 2022;18(2):118–126. (In Russ.) DOI: 10.20996/1819-6446-2022-04-03.

[4] Погосова Н.В., Палеев Ф.Н., Аушева А.К., Кучиев Д.Т., Гаман С.А., Веселова Т.Н., Белькинд М.Б., Соколова О.Ю., Жетишева Р.А., Терновой С.К., Бойцов С.А. Последствия COVID-19 на отдалённом этапе после госпитализации. Рациональная фармакотерапия в кардиологии. 2022;18(2):118–126. DOI: 10.20996/1819-6446-2022-04-03.

[5] Xie Y, Al-Aly Z. Risks and burdens of incident diabetes in long COVID: A cohort study. Lancet Diabetes Endocrinol. 2022;10(5):311–321. DOI: 10.1016/S2213-8587(22)00044-4.

[6] Galiullina MS, Khaliullina SV, Khaertynov KS, Gataullin MR, Martynova TM, Anokhin VA. Breakthrough COVID-19 infection according to the infectious diseases hospital. Kazan Medical Journal. 2022;103(4):541–551. (In Russ.) DOI: 10.17816/KMJ2022-541.

[7] Галиуллина М.Ш., Халиуллина С.В., Хаертынов Х.С., Гатауллин М.Р., Мартынова Т.М., Анохин В.А. Прорывная инфекция COVID-19 по данным инфекционного стационара. Казанский медицинский журнал. 2022;103(4):541–551. DOI: 10.17816/KMJ2022-541.

[8] Vechorko VI, Averkov OV, Zimin AA. New SARS-CoV-2 omicron variant — clinical picture, treatment, prevention (literature review). Cardiovascular Therapy and Prevention. 2022;21(6):3228. (In Russ.) DOI: 10.15829/1728-8800-2022-3228.

[9] Вечорко В.И., Аверков О.В., Зимин А.А. Новый штамм SARS-CoV-2 омикрон — клиника, лечение, профилактика (обзор литературы). Кардиоваскулярная терапия и профилактика. 2022;21(6):3228. DOI: 10.15829/1728-8800-2022-3228.

[10] Suresh A, Joshi A, Desai AK, Juturu U, Kurian DJ, Jain P, Kulkarni RD, Kumar N. COVID-19-associated fungal osteomyelitis of jaws and sinuses: An experience-driven management protocol. Med Mycol. 2022;60(2):myab082. DOI: 10.1093/mmy/myab082.

[11] Mehta S, Pandey A. Rhino-orbital mucormycosis associated with COVID-19. Cureus. 2020;12(9):e10726. DOI: 10.7759/cureus.10726.

[12] Selarka L, Sharma S, Saini D, Sharma S, Batra A, Waghmare VT, Dileep P, Patel S, Shah M, Parikh T, Darji P, Patel A, Goswami G, Shah A, Shah S, Lathiya H, Shah M, Sharma P, Chopra S, Gupta A, Jain N, Khan E, Sharma VK, Sharma AK, Chan ACY, Ong JJY. Mucormycosis and COVID-19: An epidemic within a pandemic in India. Mycoses. 2021;64(10):1253–1260. DOI: 10.1111/myc.13353.

[13] Sen M, Honavar SG, Bansal R, Sengupta S, Rao R, Kim U, Sharma M, Sachdev M, Grover AK, Surve A, Budharapu A, Ramadhin AK, Tripathi AK, Gupta A, Bhargava A, Sahu A, Khairnar A, Kochar A, Madhavani A, Shrivastava AK, Desai AK, Paul A, Ayyar A, Bhatnagar A, Singhal A, Nikose AS, Bhargava A, Tenagi AL, Kamble A, Nariani A, Patel B, Kashyap B, Dhawan B, Vohra B, Mandke C, Thrishulamurthy C, Sambare C, Sarkar D, Mankad DS, Maheshwari D, Lalwani D, Kanani D, Patel D, Manjandavida FP, Godhani F, Agarwal GA, Ravulaparthi G, Shilpa GV, Deshpande G, Thakkar H, Shah H, Ojha HR, Jani H, Gontia J, Mishrikotkar JP, Likhari K, Prajapati K, Porwal K, Koka K, Dharawat KS, Ramamurthy LB, Bhattacharyya M, Saini M, Christy MC, Das M, Hada M, Panchal M, Pandharpurkar M, Ali MO, Porwal M, Gangashetappa N, Mehrotra N, Bijlani N, Gajendragadkar N, Nagarkar NM, Modi P, Rewri P, Sao P, Patil PS, Giri P, Kapadia P, Yadav P, Bhagat P, Parekh R, Dyaberi R, Chauhan RS, Kaur R, Duvesh RK, Murthy R, Dandu RV, Kathiara R, Beri R, Pandit R, Rani RH, Gupta R, Pherwani R, Sapkal R, Mehta R, Tadepalli S, Fatima S, Karmarkar S, Patil SS, Shah S, Shah S, Shah S, Dubey S, Gandhi S, Kanakpur S, Mohan S, Bhomaj S, Kerkar S, Jariwala S, Sahu S, Tara S, Maru SK, Jhavar S, Sharma S, Gupta S, Kumari S, Das S, Menon S, Burkule S, Nisar SP, Kaliaperumal S, Rao S, Pakrasi S, Rathod S, Biradar SG, Kumar S, Dutt S, Bansal S, Ravani SA, Lohiya S, Ali Rizvi SW, Gokhale T, Lahane TP, Vukkadala T, Grover T, Bhesaniya T, Chawla U, Singh U, Une VL, Nandedkar V, Subramaniam V, Eswaran V, Chaudhry VN, Rangarajan V, Dehane V, Sahasrabudhe VM, Sowjanya Y, Tupkary Y, Phadke Y; members of the Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC) Study Group. Epidemiology, clinical profile, management, and outcome of COVID-19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India — Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC), Report 1. Indian J Ophthalmol. 2021;69(7):1670–1692. DOI: 10.4103/ijo.IJO_1565_21.

[14] Temporary guidelines “Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)”. Version 14 (12/27/2021). https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/041/original/ВМР_COVID-19_V14_27-12-2021.pdf (access date: 13.12.2022). (In Russ.)

[15] Временные методические рекомендации �Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)�. Версия 14 (27.12.2021). https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/059/041/original/ВМР_COVID-19_V14_27-12-2021.pdf (дата обращения: 13.12.2022).

[16] Volodina VD, Babkova AA, Serova NS, Reshetov IV. Fungal osteomyelitis of the skull in patients after COVID-19 associated pneumonia. Head and neck. Russian Journal. 2022;10(3):53–59. (In Russ.) DOI: 10.25792/HN.2022.10.3.53-59.

[17] Володина В.Д., Бабкова А.А., Серова Н.С., Решетов И.В. Грибковый остеомиелит черепа у пациентов после перенесённой COVID-19 пневмонии. Голова и шея. Российский журнал. 2022;10(3):53–59. DOI: 10.25792/HN.2022.10.3.53-59.

[18] Solovyov MM, Katinas EB, Karpischenko SA, Kurus AA, Zubareva AA. Invasive mycosis? Or maxillary infarction? Folia Otorhinolaryngologiae et Pathologiae Respiratoriae. 2021;27(4):71–80. (In Russ.) DOI: 10.33848/foliorl23103825-2021-27-4-71-80.

[19] Соловьев М.М., Катинас Е.Б., Карпищенко С.А., Курусь А.А., Зубарева А.А. Инвазивный микоз? Или инфаркт верхней челюсти? Folia Otorhinolaryngologiae et Pathologiae Respiratoriae. 2021;27(4):71–80. DOI: 10.33848/foliorl23103825-2021-27-4-71-80.

[20] Mañón VA, Balandran S, Young S, Wong M, Melville JC. COVID-associated avascular necrosis of the maxilla — A rare, new side effect of COVID-19. J Oral Maxillofac Surg. 2022;80(7):1254–1259. DOI: 10.1016/j.joms.2022.04.015.

[21] Al-Mahalawy H, El-Mahallawy Y, Dessoky NY, Ibrahim S, Amer H, Ayad HM, El Sherif HM, Shabaan AA. Post-COVID-19 related osteonecrosis of the jaw (PC-RONJ): An alarming morbidity in COVID-19 surviving patients. BMC Infect Dis. 2022;22(1):544. DOI: 10.1186/s12879-022-07518-9.

[22] Shukhrat BA, Dar-Odeh N, Dilnoza BT, Dildora RA, Matluba KA, Yokub KK, Ravshan UZ, Gulbahor RE. Radiographic and clinical analysis of cranio-maxillofacial complications of cavernous sinus thrombosis among 256 COVID-19 patients. J Craniofac Surg. 2022;33(5):1549–1553. DOI: 10.1097/SCS.0000000000008680.

[23] Bobamuratova DT, Boymuradov SA, Dar-Odeh NS, Kurbanov YK, Umarov RZ. Impact of COVID-19 disease and its treatment on the development of maxillofacial complications. Advances in Oral and Maxillofacial Surgery. 2021;4:100169. DOI: 10.1016/j.adoms.2021.100169.

[24] Basin EM. Osteonekrozy chelyustey. Atlas. (Osteonecrosis of the jaws. Atlas.) M.: Pero; 2021. 194 p. (In Russ.)

[25] Басин Е.М. Остеонекрозы челюстей. Атлас. М.: Перо; 2021. 194 с.

[26] Spevak EM, Christophorando DYu, Shutov VA, Ermakova AV. Prevention of drug-induced osteonecrosis of the jaw in cancer patients. Creative surgery and oncology. 2022;12(2):151–158. (In Russ.) DOI: 10.24060/2076-3093-2022-12-2-151-158.

[27] Спевак Е.М., Христофорандо Д.Ю., Шутов В.А., Ермакова А.В. Профилактика лекарственного остеонекроза челюстей у онкологических пациентов. Креативная хирургия и онкология. 2022;12(2):151–158. DOI: 10.24060/2076-3093-2022-12-2-151-158.

[28] Vinogradova NG, Lvov KV, Kharitonova MP. Prevalence and clinical features of drug-related osteonecroses of the jaws. Actual problems in dentistry. 2017;13(4):38–42. (In Russ.) DOI: 10.18481/2077-7566-2017-13-4-38-42.

[29] Виноградова Н.Г., Львов К.В., Харитонова М.П. Распространённость и клинические особенности медикаментозно ассоциированных остеонекрозов челюстей. Проблемы стоматологии. 2017;13(4):38–42. DOI: 10.18481/2077-7566-2017-13-4-38-42.

[30] Baranova IB, Yaremenko AI, Zubareva AA, Karpischenko SA, Popova MO, Kurus AA, Portnov GV, Pinegina ON, Lukina OV, Malyarevskaya MV, Kalakuckiy IN, Ilyukhina MO, Klimko NN. Mucormycosis of the bones of the facial skull, nasal cavity and par anasal sinuses in patients with COVID-19. Clinical Microbiology and Antimicrobial Chemotherapy. 2021;23(4):347–358. (In Russ.) DOI: 10.36488/cmac.2021.4.347-358.

[31] Баранова И.Б., Яременко А.И., Зубарева А.А., Карпищенко С.А., Попова М.О., Курусь А.А., Портнов Г.В., Пинегина О.Н., Лукина О.В., Маляревская М.В., Калакуцкий И.Н., Илюхина М.О., Климко Н.Н. Мукормикоз костей лицевого черепа, полости носа и околоносовых пазух у пациентов, перенёсших COVID-19. Клиническая микробиология и антимикробная химиотерапия. 2021;23(4):347–358. DOI: 10.36488/cmac.2021.4.347-358.

[32] Baranova IB, Popova MO, Yaremenko AI, Zubkova NV, Pinegina ON, Nikolaev IY. Invasive mucormycosis affecting maxillofacial region in oncohematological patients undergoing chemotherapeutic treatment and transplantation of hematopoietic stem cells. Stomatologiya. 2022;101(2):80-86. (In Russ.) DOI: 10.17116/stomat202210102180.

[33] Баранова И.Б., Попова М.О., Яременко А.И., Зубкова Н.В., Пинегина О.Н., Николаев И.Ю. Инвазивный мукормикоз с поражением органов челюстно-лицевой области у онкогематологических больных на фоне химиотерапевтического лечения и трансплантации гемопоэтических стволовых клеток. Стоматология. 2022;101(2):80-86. DOI: 10.17116/stomat202210102180.

[34] Khostelidi SN, Zaytsev VA, Vartanyan SA, Nikitin NA, Evtukh GN, Gilalov MN, Portnov GV, Zubareva AA, Baranova IB, Bogomolova TS, Avdeenko YuL, Shadrivova OV, Desyatik EA, Shagdileeva EV, Borzova YuV, Krivolapov YuA, Vasilyeva NV, Klimko NN. Mucormycosis in patients with COVID-19 in Russia: the results of a prospective multi-center study. Zhurnal infektologii. 2022;14(2):116–127. (In Russ.) DOI: 10.22625/2072-6732-2022-14-2-116-127.

[35] Хостелиди С.Н., Зайцев В.А., Вартанян С.А., Никитин Н.А., Евтух Г.Н., Гилялов М.Н., Портнов Г.В., Зубарева А.А., Баранова И.Б., Богомолова Т.С., Авдеенко Ю.Л., Шадривова О.В., Десятик Е.А., Шагдилеева Е.В., Борзова Ю.В., Криволапов Ю.А., Васильева Н.В., Климко Н.Н. Мукормикоз у больных COVID-19 в России: результаты проспективного многоцентрового исследования. Журнал инфектологии. 2022;14(2):116–127. DOI: 10.22625/2072-6732-2022-14-2-116-127.

[36] Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, Sorrell TC, Bassetti M, Akan H, Alexander BD, Andes D, Azoulay E, Bialek R, Bradsher RW, Bretagne S, Calandra T, Caliendo AM, Castagnola E, Cruciani M, Cuenca-Estrella M, Decker CF, Desai SR, Fisher B, Harrison T, Heussel CP, Jensen HE, Kibbler CC, Kontoyiannis DP, Kullberg BJ, Lagrou K, Lamoth F, Lehrnbecher T, Loeffler J, Lortholary O, Maertens J, Marchetti O, Marr KA, Masur H, Meis JF, Morrisey CO, Nucci M, Ostrosky-Zeichner L, Pagano L, Patterson TF, Perfect JR, Racil Z, Roilides E, Ruhnke M, Prokop CS, Shoham S, Slavin MA, Stevens DA, Thompson GR, Vazquez JA, Viscoli C, Walsh TJ, Warris A, Wheat LJ, White PL, Zaoutis TE, Pappas PG. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2020;71(6):1367–1376. DOI: 10.1093/cid/ciz1008.

[37] Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India. Diabetes Metab Syndr. 2021;15(4):102146. DOI: 10.1016/j.dsx.2021.05.019.

[38] Eremin DA, Khelminskaya NM, Kravets VI, Posadskaya AV, Pletayanova IV, Kravets AV, Faustova EE, Nikolskaya IA. Risks and possible complications in maxillofacial surgery patients during or after coronavirus infection. Medical alphabet. 2022;(2):67–70. (In Russ.) DOI: 10.33667/2078-5631-2022-2-67-70.

[39] Еремин Д.А., Хелминская Н.М., Кравец В.И., Посадская А.В., Плетянова И.В., Кравец А.В., Фаустова Е.Е., Никольская И.А. Риски и возможные осложнения у пациентов челюстно-лицевой хирургии в процессе или после перенесённой коронавирусной инфекции. Медицинский алфавит. 2022;(2):67–70. DOI: 10.33667/2078-5631-2022-2-67-70.

[40] Kuzmina EV, Borovoy VN, Sotnikova MV, Lis ES, Dovgan EV, Kovalkova PA. Diagnosis of rhinocerebral mucormycosis as complication of COVID-19, features of patient’s treatment. Clinical Dentistry (Russia). 2022;25(2):82–92. (In Russ.) DOI: 10.37988/1811-153X_2022_2_82.

[41] Кузьмина Е.В., Боровой В.Н., Сотникова М.В., Лис Е.С., Довгань Е.В., Ковалькова П.А. Диагностика риноцеребрального мукормикоза как осложнения COVID-19 и особенности лечения пациентов. Клиническая стоматология. 2022;25(2):82–92. DOI: 10.37988/1811-153X_2022_2_82.

[42] Ermilov VV, Smirnov AV, Dorofeev NA, Grigor’eva NV, Tarasova NV, Kushniruk PI, Karadzhe M, Barkanov VB, Chernetsky OA, Poplavsky AE, Nesterova AA, Lozovik VV, Somova VV. COVID-19-associated mucormycosis in ophthalmological practice in the Volgograd region. Arkhiv Patologii. 2022;84(5):43–49. (In Russ.) DOI: 10.17116/patol20228405143.

[43] Ермилов В.В., Смирнов А.В., Дорофеев Н.А., Григорьева Н.В., Тарасова Н.В., Кушнирук П.И., Карадже М., Барканов В.Б., Чернецкий О.А., Поплавский А.Э., Нестерова А.А., Лозовик В.В., Сомова В.В. COVID-19-ассоциированный мукормикоз в офтальмологической практике Волгоградского региона. Архив патологии. 2022;84(5):43–49. DOI: 10.17116/patol20228405143.

[44] Savosin YuV, Shafranova SK, Gaivoronskaya TV, Avdeeva MG, Vartanyan SA. Rhinocerebral form of invasive mycosis in COVID-19 patients: clinical course, diagnosis, treatment experience. Kuban Scientific Medical Bulletin. 2022;29(5):63–79. (In Russ.) DOI: 10.25207/1608-6228-2022-29-5-63-79.

[45] Савосин Ю.В., Шафранова С.К., Гайворонская Т.В., Авдеева М.Г., Вартанян С.А. Риноцеребральная форма инвазивных микозов у пациентов, перенёсших новую коронавирусную инфекцию COVID-19: клиника, диагностика, опыт лечения. Проспективное неконтролируемое одномоментное исследование. Кубанский научный медицинский вестник. 2022;29(5):63–79. DOI: 10.25207/1608-6228-2022-29-5-63-79.

[46] Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A, Gangneux JP, Nasir N, Bonifaz A, Araiza J, Klimko N, Serris A, Lagrou K, Meis JF, Cornely OA, Perfect JR, White PL, Chakrabarti A; ECMM and ISHAM collaborators. The emergence of COVID-19 associated mucormycosis: A review of cases from 18 countries. Lancet Microbe. 2022;3(7):543–552. DOI: 10.1016/S2666-5247(21)00237-8.

[47] Bhattacharyya A, Sarma P, Sharma DJ, Das KK, Kaur H, Prajapat M, Kumar S, Bansal S, Prakash A, Avti P, Thota P, Reddy DH, Gautam BS, Medhi B. Rhino-orbital-cerebral-mucormycosis in COVID-19: A systematic review. Indian J Pharmacol. 2021;53(4):317–327. DOI: 10.4103/ijp.ijp_419_21.

[48] Kamat M, Datar U, Byakodi S, Kamat S, Vimal Kumar V. COVID-19-associated mucormycosis of head-and-neck region: A systematic review. J Clin Transl Res. 2022;8(1):31–42. PMID: 35187287.

[49] Kumar S, Choudhary R, Pandey VP. “MuCovid-21” study: Mucormycosis at an Indian tertiary care centre during the COVID-19 pandemic. J R Coll Physicians -Edinb. 2021;51(4):352–358. DOI: 10.4997/JRCPE.2021.407.

[50] Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. 2021;24(11):1522–1533. DOI: 10.1038/s41593-021-00926-1.

[51] Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American Association of Oral and Maxillofacial Surgeons' position paper on medication-related osteonecrosis of the jaws-2022 update. J Oral Maxillofac Surg. 2022;80(5):920–943. DOI: 10.1016/j.joms.2022.02.008.

[52] Wang A, Ren M, Wang J. The pathogenesis of steroid-induced osteonecrosis of the femoral head: A systematic review of the literature. Gene. 2018;671:103–109. DOI: 10.1016/j.gene.2018.05.091.

[53] Shetty GM. Double trouble-COVID-19 and the widespread use of corticosteroids: Are we staring at an osteonecrosis epidemic? Indian J Orthop. 2021;56(2):226–236. DOI: 10.1007/s43465-021-00546-8.

[54] Angulo-Ardoy M, Ureña-Aguilera Á. Knee osteonecrosis after COVID-19. Fam Pract. 2021;38(1):45–47. DOI: 10.1093/fampra/cmab063.

[55] Torgashin AN, Rodionova SS. Osteonecrosis in patients recovering from COVID-19: mechanisms, diagnosis, and treatment at early-stage disease (review). Traumatology and Orthopedics of Russia. 2022;28(1):128–137. (In Russ.) DOI: 10.17816/2311-2905-1707.

[56] Торгашин А.Н., Родионова С.С. Остеонекроз у пациентов, перенёсших COVID-19: механизмы развития, диагностика, лечение на ранних стадиях (обзор литературы). Травматология и ортопедия России. 2022;28(1):128–137. DOI: 10.17816/2311-2905-1707.

[57] Sulewski A, Sieroń D, Szyluk K, Dąbrowski M, Kubaszewski Ł, Lukoszek D, Christe A. Avascular necrosis bone complication after active COVID-19 infection: Preliminary results. Medicina (Kaunas). 2021;57(12):1311. DOI: 10.3390/medicina57121311.

[58] Malyarevskaya MV, Lukina OV, Zubareva AA, Bubnova EV, Baranova IB, Yaremenko АI, Popova MO. Invasive mucormycosis of nasal cavity, paranasal sinuses, bones of the skull in post COVID-19 patients: prospective study. Dia-gnostic radiology and radiotherapy. 2022;13(3):28–42. (In Russ.) DOI: 10.22328/2079-5343-2022-13-3-28-42.

[59] Маляревская М.В., Лукина О.В., Зубарева А.А., Бубнова Е.В., Баранова И.Б., Яременко А.И., Попова М.О. Лучевая диагностика инвазивного мукормикоза полости носа, околоносовых пазух, костей черепа у пациентов, перенёсших новую коронавирусную инфекцию (COVID-19): проспективное исследование. Лучевая диагностика и терапия. 2022;13(3):28–42. DOI: 10.22328/2079-5343-2022-13-3-28-42.

[60] Singh H, Dua S, Goel A, Dhar A, Bhadauria V, Garg A, Katyar V, Sharma S, Shukla A. Rhino-orbital-cerebral mucormycosis in times of COVID-19: A neurosurgical experience. Surg Neurol Int. 2021;12:538. DOI: 10.25259/SNI_772_2021.

[61] Shahinian GG, Kareva SA, Markarov AE, Sharov AV, Lyubimov SN, Sarshor SV. Osteomyelitis of the skull bones in post COVID-19 patients. Russian neurosurgical journal named after professor AL Polenov. 2022;14(2):160–166. (In Russ.)

[62] Шагинян Г.Г., Карева С.А., Маркаров А.Э., Шаров А.В., Любимов С.Н., Саршор С.В. Интракраниальные гнойно-воспалительные осложнения у пациентов, перенёсших COVID-19. Российский нейрохирургический журнал им. проф. А.Л. Поленова. 2022;14(2):160–166. EDN: SCJPVW.

[63] Haidry N, Bhavana K, Shivhare P, Kumar V, Vaidyanathan A. A rare case of mandibular mucormycosis in a post-COVID-19 patient. Cureus. 2022;14(8):28216. DOI: 10.7759/cureus.28216.

[64] Ambereen A, Rahman SA, Rehman S, Zaidi K, Arif SH. Mandibular mucormycosis following SARS-CoV-2 infection — A case report and review of literature. Clin Infect Pract. 2021;12:100099. DOI: 10.1016/j.clinpr.2021.100099.

[65] Bhanumurthy L, Krishna PS, Sekhar P, Makesh Raj LS. Post coronavirus disease mucormycosis involving the mandible: A case report with brief note on literature. J Oral Maxillofac Pathol. 2021;25(3):407–410. DOI: 10.4103/jomfp.jomfp_355_21.

[66] Sood A, Nayyar V, Roychoudhury A, Bhalla AS, Mishra D. Post-COVID steroid induced avascular necrosis of the jaw: Emerging challenge in India. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022:S2212-4403(22)01122-1. DOI: 10.1016/j.oooo.2022.08.014.

[67] Mani S, Thirunavukkarasu A. A clinico-pathological study of COVID-19 associated rhino-orbital-cerebral mucormycosis. Indian J Ophthalmol. 2022;70(3):1013–1018. DOI: 10.4103/ijo.IJO_2366_21.

[68] Turbin RE, Wawrzusin PJ, Sakla NM, Traba CM, Wong KG, Mirani N, Eloy JA, Nimchinsky EA. Orbital cellulitis, sinusitis and intracranial abnormalities in two adolescents with COVID-19. Orbit. 2020;39(4):305–-310. DOI: 10.1080/01676830.2020.1768560.

[69] Slavkova N, Nedevska M. Aseptic osteonecrosis of the maxilla after severe COVID-19 infection and its treatment. Radiol Case Rep. 2022;17(9):3228–3232. DOI: 10.1016/j.radcr.2022.06.009.

[70] Chereshneva ND, Chernykh TF, Krasilnikov AV. Optimization of COVID-19 drug therapy costs based on pharmacoeconomic analysis. Medical & pharmaceutical journal “Pulse”. 2022;24(7):9–14. (In Russ.) DOI: 10.26787/nydha-2686-6838-2022-24-7-9-14.

[71] Черешнева Н.Д., Черных Т.Ф., Красильников А.В. Оптимизация затрат на лекарственную терапию COVID-19 на основе фармакоэкономического анализа. Медико-фармацевтический журнал �Пульс�. 2022;24(7):9–14. DOI: 10.26787/nydha-2686-6838-2022-24-7-9-14.

[72] Balushi AA, Ajmi AA, Sinani QA, Menon V, Berieki ZA, Shezawi AA, Azri SA, Rashdi AA, Jardani AA, Baluki TA, Ghaithi SA, Reesi AA, Al-Za'abi AT, Al' Balushi MA, Maqbali TA. COVID-19-associated mucormycosis: An opportunistic fungal infection. A case series and review. Int J Infect Dis. 2022;121:203–210. DOI: 10.1016/j.ijid.2022.05.005.

[73] Pakdel F, Ahmadikia K, Salehi M, Tabari A, Jafari R, Mehrparvar G, Rezaie Y, Rajaeih S, Alijani N, Barac A, Abdollahi A, Khodavaisy S. Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran. Mycoses. 2021;64(10):1238–1252. DOI: 10.1111/myc.13334.

[74] Moorthy A, Gaikwad R, Krishna S, Hegde R, Tripathi KK, Kale PG, Rao PS, Haldipur D, Bonanthaya K. SARS-CoV-2, uncontrolled diabetes and corticosteroids-an unholy trinity in invasive fungal infections of the maxillofacial region? A retrospective, multi-centric analysis. J Maxillofac Oral Surg. 2021;20(3):418–425. DOI: 10.1007/s12663-021-01532-1.

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