The role of microRNAs in the development of gastric and duodenal ulcers
Yulia R. Sagadatova , Anvar G. Khasanov , Irina R. Gilyazova , Damir I. Sufiyarov , Ildar F. Sufiyarov
Kazan medical journal ›› 2023, Vol. 104 ›› Issue (4) : 534 -540.
The role of microRNAs in the development of gastric and duodenal ulcers
The research highlights the fundamental concepts of microRNA, the mechanisms of RNA interference, the importance of microRNA in the development of diseases. Combining the experience of domestic and foreign researchers, the authors identified the main miRNAs involved in the development of gastric and duodenal ulcers. The article also describes the main mechanisms of regulation of the inflammatory process in gastric and duodenal ulcers associated with Helicobacter pylori, the influence of microorganisms on the expression of various microRNA types and the control of the cellular immune response. In addition, the review presents the latest research on methods for diagnosing Helicobacter pylori-associated peptic ulcer based on the determination of circulating microRNAs. The results of an experimental model of treatment of patients infected with Helicobacter pylori with drugs that act on non-coding RNA are presented.
microRNA / peptic ulcer / morbidity / complicated gastric and duodenal ulcer / review
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