Cytokine status of patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus

Abstract

The review article is devoted to an actual problem of modern medicine - combined pathology of chronic obstructive pulmonary disease and type 2 diabetes mellitus. These 2 diseases take the first place in the structure of people’s mortality. The rate of chronic obstructive pulmonary disease and type 2 diabetes mellitus increases annually along with life length and according to different data reaches 35.8%. In the article scientists’ modern perception and known facts from scientific literature are presented. Special attention is given to cytokine status in chronic obstructive pulmonary disease and type 2 diabetes mellitus. Cytokines classification based on mechanism of action and their role in pathogenesis is presented. Systemic inflammation characteristic for both diseases presents as the increase of pro-inflammatory cytokines level in the blood and decrease of anti-inflammatory cytokines. Determining cytokines in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus has prognostic value. Mutual negative influence of these two diseases is directly associated with the increase of pro-inflammatory cytokines which are considered the reason for insulin resistance and type 2 diabetes mellitus. Despite the attempts to study cytokine status in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus the issues of treatment of combined pathology, diagnostic concentration of pro-inflammatory and anti-inflammatory cytokines, their role in pathogenesis and clinical presentation are still an open question. Certainly it is necessary to continue studying the cytokine status in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus to answer those questions.

Keywords

cytokines / chronic obstructive pulmonary disease / type 2 diabetes mellitus / pathogenesis

RIGHTS & PERMISSIONS

Nedomolkina S.A., Velikaya O.V., Zoloedov V.I.