Experience of cooperation in the creation of hematopoietic stem cells donors registry

M A Murzabekova; J S Neredko; Ya M Marchenko

doi:10.17750/KMJ2016-777

Kazan medical journal ›› 2016, Vol. 97 ›› Issue (5) : 777 -780. DOI: 10.17750/KMJ2016-777

Hygiene and healthcare management

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Experience of cooperation in the creation of hematopoietic stem cells donors registry

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Abstract

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Aim. To evaluate the experience of participating in the creation of a national registry of hematopoietic stem cells donors.

Methods. Potential hematopoietic stem cells donor filled out a questionnaire, after the examination, he was assigned an individual donor code (bar code). The results of typing and questionnaires are placed on the registry of potential hematopoietic stem cells donors. Maintenance of HLA-typed potential hematopoietic stem cells donors registry and the selection of compatible «donor-recipient» pairs in RMSPC «Rosplazma» were performed using a specialized program «Prometheus» (Steiner Ltd., Czech Republic).

Results. 484 donors, who were indigenous peoples of Stavropol and Stavropol Krai, as well as representatives of the North Caucasus small nations of different nationalities, were included into the registry for the period from 08.20.2013 to 20.06.2014. Age ranged from 19 to 42 years. As of 31.10.2015, 31 491 potential hematopoietic stem cells donors (54% - female, 46% - male) were included into the registry, 28 509 donors were typed: 24 310 for HLA - A, B, C, and DRB1 loci; 2305 for HLA - A, B, C, DRB1, and DQB1 loci; 1894 for HLA - A, B, and DRB1 loci. The registry has the highest number of A-B-DRB1 typed donors among Russian registries. New HLA-alleles in the Russian populations were revealed in 57 cases for 28 509 typing (1:500).

Conclusion. There is a clear need to enhance cooperation of RMSPC «Rosplazma» with all regions of Russia and create unified national registry of hematopoietic stem cells donors with its inclusion in international databases.

Keywords

HLA-typing / hematopoietic stem cells / donor registry / genetic polymorphisms

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M A Murzabekova, J S Neredko, Ya M Marchenko. Experience of cooperation in the creation of hematopoietic stem cells donors registry. Kazan medical journal, 2016, 97(5): 777-780 DOI:10.17750/KMJ2016-777

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