The skin microbiota in pregnant women suffering from atopic dermatitis
A Yu Lonshakova-Medvedeva , K N Monakhov , A N Suvorov , O V Lavrova
Kazan medical journal ›› 2016, Vol. 97 ›› Issue (2) : 222 -229.
The skin microbiota in pregnant women suffering from atopic dermatitis
Aim. To study the skin microbiota of pregnant women suffering from atopic dermatitis.
Methods. 53 women of reproductive age suffering from atopic dermatitis (28 pregnant and 25 non-pregnant) were examined. The control group included dermatologically healthy women (25 pregnant and 25 non-pregnant). Prior to treatment initiation and on 15-day of study pathological process spread, the SCORAD index (scoring of atopic dermatitis - atopic dermatitis severity assessment), dermatology life quality index determination were conducted. In addition, microbiological study of material taken from the forehead, elbow bend skin and visually unaltered forearm skin was performed.
Results. In women (pregnant and non-pregnant), suffering from atopic dermatitis skin total bacterial load is increased. In all groups, the skin microbiota is presented mainly by staphylococci: in dermatologically healthy people - coagulase-negative, in atopic dermatitis - Staphylococcusя aureus. In atopic dermatitis Staphylococcus aureus is isolated from both lesions and visually unaltered skin. In pregnant women with atopic dermatitis skin bacterial load was higher, Staphylococcus aureus was found more commonly. The skin microbiota in dermatologically healthy women was more diverse in respect of species comparing with patients with atopic dermatitis. Basic care remedies use leads to clinical improvement and a decrease in the skin total bacterial load and Staphylococcus aureus load. Daily use of emollients has no effect on saprophytic microorganisms.
Conclusion. In pregnant patients with atopic dermatitis higher skin total bacterial load and higher rate of skin colonization by Staphylococcus aureus are observed.
atopic dermatitis / Staphylococcus aureus / microbiota / pregnancy
| [1] |
Горячкина Л.А., Кашкин К.П. Клиническая аллергология и иммунология: руководство для практикующих врачей. М.: Миклош. 2011; 432 с. |
| [2] |
Мокроносова М.А. Влияние Staphylococcus aureus на течение атопического дерматита. Аллергология. 2003; (1): 46-50. |
| [3] |
Нобл У.К. Микробиология кожи человека. Пер. с англ. М.: Медицина. 1986; 372 с. |
| [4] |
Петухова A.B., Падруль М.М. Клинико-лабораторные особенности течения беременности при аллергической патологии. Врач-аспирант. 2010; 5.1 (42): 211-216. |
| [5] |
Серов В.Н. Руководство по практическому акушерству. М.: МИА. 1997; 440 с. |
| [6] |
Федеральные клинические рекомендации по ведению пациентов с атопическим дерматитом. Национальные клинические рекомендации. Российское общество дерматовенерологов и косметологов. М. 2013; 42 с. |
| [7] |
Шеварова В.Н., Суворова К.Н., Фадеева В.И., Кузнецова Т.С. Атопический дерматит у беременных. Вестн. дерматол. 1989; 12: 31-32. |
| [8] |
Breuer K., Wittmann M., Bosche B. et al. Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). Allergy. 2000; 55: 551-555. http://dx.doi.org/10.1034/j.1398-9995.2000.00432.x |
| [9] |
Hanifin J.M., Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venerol. Suppl. (Stockh.). 1980; 92: 44-47. |
| [10] |
Kemmett D., Tidman M.J. The influence of menstrual cycle and pregnancy on atopic dermatitis. Br J Dermatol. 1991; 125: 59-61. http://dx.doi.org/10.1111/j.1365-2133.1991.tb06041.x |
| [11] |
Lever R. Infection in atopic dermatitis. Dermatol Therapy. 1996; 1: 32-37. |
| [12] |
Mendoza M., Meugnier H., Bes M. et al. Identification of Staphylococcus species by 16s-23s rDNA intergenic spacer PCR analysis. Intern J Syst Bacteriol. 1998; 48, 1049-1055. http://dx.doi.org/10.1099/00207713-48-3-1049 |
| [13] |
Na S.Y., Roh J.Y., Kim J.M. et al. Analysis of colonization and genotyping of the exotoxins of Staphylococcus aureus in patients with atopic dermatitis. Ann Dermatol. 2012; 24: 413-419. http://dx.doi.org/10.5021/ad.2012.24.4.413 |
| [14] |
Rieg S., Steffen H., Seeber S. et al. Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. J Immunology. 2005; 174: 8003-8010. http://dx.doi.org/10.4049/jimmunol.174.12.8003 |
| [15] |
Suhyun Cho, Hee Jung Kim, Sang Ho Oh et al. The influence of pregnancy and menstruation on the deterioration of atopic dermatitis symptoms. Ann Dermatol. 2010; 22 (2): 180-185. http://dx.doi.org/10.5021/ad.2010.22.2.180 |
Lonshakova-Medvedeva A.Y., Monakhov K.N., Suvorov A.N., Lavrova O.V.
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