Pathophysiological disturbances in complicated pancreatic pseudocysts
O Yu Gerbali , I A Krivoruchko , N N Goncharova
Kazan medical journal ›› 2015, Vol. 96 ›› Issue (2) : 191 -197.
Pathophysiological disturbances in complicated pancreatic pseudocysts
Aim. To determine profibrogenic mediators, markers of endothelial dysfunction and hemostasis in patients with different types of complicated pancreatic pseudocysts.
Methods. The study included 47 patients aged 43.58±7.38 years: 42 males and 5 females. The patients were allocated to three groups based on the classification of pancreatic pseudocysts by A. D’Egidio and М. Schein (1991). All patients underwent surgery. Serum levels of vascular endothelial growth factor, matrix metalloproteinase-9, matrix metalloproteinase-2 tissue inhibitor, the complex of metalloproteinase-9 and inhibitor, plasma levels of interleukin-6, -8, -18 and -10 were determined by ELISA method. Blood glutathione peroxidase activity and malondialdehyde serum level were determined by spectrophotometry.
Results.Levels of Interleukin-6, -8 and -18 was higher in patients with type I of pseudocysts compared to control (p
Conclusion. Increased concentration of matrix metalloproteinase-2 tissue inhibitor and increased inhibition coefficient in patients with chronic pancreatitis may reflect favorable conditions for pancreatic remodeling and fibrosis.
pancreatic pseudocyst / complications / cytokines / matrix metalloproteinases
Gerbali O.Y., Krivoruchko I.A., Goncharova N.N.
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