Experimental studies of effectiveness of a new mineral complex for regeneration of epithelial tissues and skin

V. Yu. Mishlanov; V. А. Chereshnev; G. P. Vdovina; А. А. Burlutskaya; А. L. Zuev; E. P. Koshurnikova; V. V. Emelkina; V. А. Samartsev; V. А. Gavrilov

doi:10.17816/pmj406148-157

Perm Medical Journal ›› 2023, Vol. 40 ›› Issue (6) :148 -157. DOI: 10.17816/pmj406148-157

Biology and experimental medicine

research-article

Experimental studies of effectiveness of a new mineral complex for regeneration of epithelial tissues and skin

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E.A. Vagner Perm State Medical University

Institute of Immunology and Physiology, Ural Branch of RAS

Perm National Research Polytechnic University

Institute of Continuous Media Mechanics of Perm Federal Research Center of Ural Branch of RAS

MD, PhD, Professor, Correspondent Member of RAS, Head of the Department of Propaedeutics of Internal Diseases №1

MD, PhD, Professor, Academician of RAS, Chief Researcher

PhD, Professor, Head of the Department of Pharmacology

researcher, Department of Pre-clinical Studies, Central Research Laboratory

Doctor of Physical and Mathematical Sciences, Associate Professor, Professor of the Department of Applied Physics, Senior Researcher

Candidate of Medical Sciences, Associate Professor, Department of Propaedeutics of Internal Diseases №1

Assistant, Department of Propaedeutics of Internal Diseases №1

MD, PhD, Professor, Head of the Department of General Surgery

Candidate of Medical Sciences, Associate Professor, Department of General Surgery

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Abstract

Objective. To study the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver in model experiments of the planar skin wounds and acute bronchitis in laboratory animals for the development of new techniques of surgical and pulmonological diseases treatment.

Materials and methods. An experimental study of the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver was carried out on models of the planar skin wounds and acute bronchitis in rats.

Results. The results of histological examination of tissues showed the advantage of the mineral complex over the control groups of animals. The anti-inflammatory and regenerative activity of the mineral complex was established in a model of acute bronchitis and regenerative activity in a model of a planar skin wound.

Conclusions. The effectiveness of the mineral complex depended on the concentration of cerium ions and was manifested at a dose of 0.003 μg/kg of animal weight.

Keywords

cerium / regeneration / experimental study / pulmonology / surgery

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V. Yu. Mishlanov, V. А. Chereshnev, G. P. Vdovina, А. А. Burlutskaya, А. L. Zuev, E. P. Koshurnikova, V. V. Emelkina, V. А. Samartsev, V. А. Gavrilov. Experimental studies of effectiveness of a new mineral complex for regeneration of epithelial tissues and skin. Perm Medical Journal, 2023, 40(6): 148-157 DOI:10.17816/pmj406148-157

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