Modern aspects of hemostasis state for fevers of rickettsiosis etiology

Abstract

To analyze the data obtained from scientific papers on Internet resources and to track the characteristic changes in hemostasis with various types of rickettsiosis fevers, allowing a better understanding of the pathogenesis of rickettsiosis and, as a result, a more competent approach to the treatment of this pathology. In the course of the work, numerous scientific papers of foreign and domestic scientists from various Internet resources (PubMed, CyberLeninka, Elibrari, etc.) were used, which made it possible to analyze changes in hemostasis and summarize them while working.

At the end of the twentieth century, a rapid economic development of endemic zones caused changes in their nosology, significantly affecting an increase in the incidence of natural focal rickettsiosis from the group of tick-borne spotted fevers in many regions of the world. Geographical conditions of the Volga-Caspian floodplain have created optimal conditions for the formation of natural foci of some rickettsioses on the territory of the Astrakhan region. During the period of controlled epidemiological surveillance from 1983 to 2019, the incidence rate of Astrakhan rickettsia fever has increased several dozen times, the settlements located near the gas complex are hyperendemic. The results of numerous studies regarding infectious diseases of rickettsiosis etiology indicate the leading role of cellular structures in the imbalance of hemostasis suggesting a more detailed study of their functional activity and the determination of factors affecting their activity. Rickettsioses require a more thorough study of the clinical and epidemiological picture, pathogenetic aspects to identify criteria for early diagnosis of hemocoagulation disorders in the hemostasis system that formed the basis of this study.

Thus, summing up all of the above, rickettsioses require a more thorough study of the clinical and epidemiological picture, pathogenetic aspects to identify criteria for early diagnosis and appointment of adequate therapy. The features of hemocoagulation dynamics in rickettsia fevers deserve special attention, because this process is both a trigger mechanism of the infectious process and an important factor affecting other structures of this biological system.

Keywords

Astrakhan rickettsia fever / hemostasis / hemorrhagic rash / vascular endothelium / platelets

References

[1] Bedlinskaya N.R. The role of functional activity of platelets and blood phagocytes in the pathogenesis of Astrakhan rickettsia fever: Dissertation for the degree of Candidate of Medical Sciences. Astrakhan: Astrakhan State Medical University 2017; 256 (in Russian).

[2] Бедлинская Н.Р. Роль функциональной активности тромбоцитов и фагоцитов крови в патогенезе Астраханской риккетсиозной лихорадки: дис. … канд. мед. наук. Астрахань: Астраханский государственный медицинский университет 2017; 256.

[3] Kabachek N.I., Galimzyanov H.M., Vasilkova V.V. Differential diagnosis of Astrakhan rickettsia fever and measles. Astrakhan Medical Journal 2009; 4: 39–43 (in Russian).

[4] Кабачек Н.И., Галимзянов Х.М., Василькова В.В. Дифференциальная диагностика Астраханской риккетсиозной лихорадки и кори. Астраханский медицинский журнал 2009; 4: 39–43.

[5] Rudakov N.V., Shpynov S.N., Samoylenko I.E., Yastrebov V.K., Obert A.S., Kurepina N.Yu. Rickettsias and rickettsioses of the tick-spot fever group in Siberia. Omsk Scientific Bulletin. 2012; 5 (in Russian).

[6] Рудаков Н.В., Шпынов С.Н., Самойленко И.Е., Ястребов В.К., Оберт А.С., Курепина Н.Ю. Риккетсии и риккетсиозы группы клещевой пятнистой лихорадки в Сибири. Омский научный вестник 2012; 5.

[7] Ugleva S.V. Astrakhan spotted fever: dynamics, territorial distribution, structure of morbidity. Caspian Bulletin of Medicine and Pharmacy 2020; 1: 43–50 (in Russian).

[8] Углева С.В. Астраханская пятнистая лихорадка: динамика, территориальное распределение, структура заболеваемости. Прикаспийский вестник медицины и фармации. 2020; 1: 43–50.

[9] Ugleva S.V., Tutelyan A.V., Shabalina S.V. Astrakhan rickettsiosis fever – tick-borne rickettsiosis on the territory of the Lower Volga region. Infectious diseases 2018; 16: 86–91 (in Russian).

[10] Углева С.В., Тутельян А.В., Шабалина С.В. Астраханская риккетсиозная лихорадка – клещевой риккетсиоз на территории Нижнего Поволжья. Инфекционные болезни 2018; 16: 86–91.

[11] Chalov V.V., Zharkova V.V. Differential diagnosis of coxyellosis and West Nile fever. Astrakhan 2007 (in Russian).

[12] Чалов В.В., Жаркова В.В. Дифференциальная диагностика коксиеллеза и лихорадки Западного Нила. Астрахань 2007.

[13] Galimzyanov H.M. Astrakhan rickettsia fever (clinic, diagnosis, treatment): dis. Doctor of Medical Sciences. Moscow 1997; 338 (in Russian).

[14] Галимзянов Х.М. Астраханская риккетсиозная лихорадка (клиника, диагностика, лечение): дис. д-ра мед. наук. М. 1997; 338.

[15] Imamutdinova N.F., Martynova O.V., Bedlinskaya N.R. Clinical and laboratory features of the course of tick-spotted fevers in the exanthematous period. Scientific and methodological electronic journal. Concept 2016; 11: 3026–3030 (in Russian).

[16] Имамутдинова Н.Ф., Мартынова О.В., Бедлинская Н.Р. Клинико-лабораторные особенности течения клещевых пятнистых лихорадок в экзантематозном периоде. Концепт: научно-методический электронный журнал 2016; 11: 3026 –3030.

[17] Parola P., Paddock K.D., Sokolovsky S., Labruna M.B., Medyannikov O., Kernif T., Abdad M.Yu., Stenos J., Bitam I., Fournier P. and Raul D. Recent data on tick-borne rickettsioses worldwide: a geographical approach. Wedge. Microbiol. Rev. 2013; 26: 657–702.

[18] Parola P., Paddock C.D., Socolovschi C., Labruna M.B., Mediannikov O., Kernif T., Abdad M.Y., Stenos J., Bitam I., Fournier P.E Raoult D. Update on tick-borne rickettsioses around the world: a geographic approach. Clin. Microbiol. Rev. 2013; 26: 657–702.

[19] Loban K.M., Lobzin Yu.V., Lukin E.P. Human Rickettsiosis (a guide for doctors). Moscow 2002; 475 (in Russian).

[20] Лобан К.М., Лобзин Ю.В., Лукин Е.П. Риккетсиозы человека (руководство для врачей). М.: СПб. 2002; 475.

[21] Lukin E.P., Vorobyev A.A., Makhlai A.A. Elements of the pathogenesis of rickettsioses in the light of modern data. Bulletin of the Russian Academy of Medical Sciences 1999. 12: 7–13 (in Russian).

[22] Лукин Е.П., Воробьев А.А., Махлай А.А. Элементы патогенеза риккетсиозов в свете современных данных. Вестник Российской академии медицинских наук 1999; 12: 7–13.

[23] Kleba B., Clark T.R., Latter E.I. et al. Destroys the Rickettsia rickettsii Sca2 auto-transporter by suppressing actin-based mobility. Infection and immunity 2010; 5: 2240–2247.

[24] Kleba B., Clark T.R., Lutter E.I. et all. Disruption of the Rickettsia rickettsii Sca2 autotransporter inhibits actin-based motility. Infection and Immunity 2010; 5: 2240–2247.

[25] Jia N., Jiang J.-F., Huo K.-B. et al. Subspecies Rickettsia sibirica BJ-90 as a cause of human diseases. N. Engl. J. Med. 2014; 12: 1176–1178.

[26] Jia N., Jiang J.-F., Huo Q.-B. et al. Rickettsia sibirica subspecies BJ-90 as a cause of human disease. N. Engl. J. Med. 2014; 12: 1176–1178.

[27] Raul D., Berbis P., Ru V., Xu Sh, Maurin M. A new tick-borne disease caused by Rickettsia slovaca. Lancet 1997; 350: 112–113.

[28] Raoult D., Berbis P., Roux V., Xu W., Maurin M. A new tick-transmitted disease due to Rickettsia slovaca. Lancet 1997; 350: 112–113.

[29] Lyskovtsev M.M. Tick-borne rickettsiosis. Clinic, treatment, diagnosis and prevention of tick–borne rickettsiosis. State Publishing House of Medical Literature. Moscow 1963; 276 (in Rus-sian).

[30] Лысковцев М.М. Клещевой риккетсиоз. Клиника, лечение, диагностика и профилактика клещевого риккетсиоза. Государственное издательство медицинской литературы. М. 1963; 276.

[31] Sakharuk O.V. Features of the clinic and the state of hemostasis in patients with tick-borne rickettsiosis. Moscow 2005; 148 (in Russian).

[32] Сахарук О.В. Особенности клиники и состояние гемостаза у больных клещевым риккетсиозом. М. 2005; 148.

[33] Nikulina L.N., Galimzyanov H.M., Rasskazov N.I. and co-author. Laser Doppler flowmetry in the assessment of peripheral microcirculation in patients with Astrakhan rickettsia fever. Infectious diseases. 2009; 7: 76–79 (in Russian).

[34] Никулина Л.Н., Галимзянов Х.М., Рассказов Н.И. и соавтор. Лазерная доплеровская флоуметрия в оценке периферической микроциркуляции у больных Астраханской риккетсиозной лихорадкой. Инфекционные болезни 2009; 7: 76–79.

[35] Fitzgerald J.R., Foster T.J., Cox D. Interaction of bacterial pathogens with platelets. Natural Microbiology 2006; 4: 445–457.

[36] Fitzgerald J.R., Foster T.J., Cox D. The interaction of bacterial pathogens with platelets. Nat Rev Microbiol. 2006; 4: 445–457.

[37] Yiman M.R. Platelets in protection from bacterial pathogens. Cell. Mol. Life Science, 2010; 67: 525–544.

[38] Yeaman M.R. Platelets in defense against bacterial pathogens. Cell. Mol. Life Sci. 2010; 67: 525–544.

[39] Klinger M.H., Jelkmann W. The role of blood platelets in infection and inflammation. J. Interferon Cytokine Res. 2002; 22: 913–922.

[40] Klinger M.H., Jelkmann W. Role of blood platelets in infection and inflammation. J. Interferon Cytokine Res. 2002; 22: 913– 922.

[41] Perlman S.J., Hunter M.S., Zchori-Fein E. The emerging diversity of rickettsias. Proceedings of the Royal Society of Great Britain. Biological Sciences 2006; 273: 2097–2106.

[42] Perlman S.J., Hunter M.S., Zchori-Fein E. The emerging diversity of Rickettsia. Proceedings of the Royal Society B. Biological Sciences. 2006; 273: 2097–2106.

[43] Vitorino L., Chelo I.M., Bacellar F., Ze-Ze L. Phylogeny of rickettsias: a multigenic approach. Microbiology 2007; 153: 160–168.

[44] Vitorino L., Chelo I.M., Bacellar F., Ze-Ze L. Rickettsiae phylogeny: a multigenic approach. Microbiology 2007; 153: 160–168.

[45] Kireeva R.Y. Tick-borne rickettsiosis of Asia. Questions of pathogenesis, clinic, diagnosis and treatment: abstract of the Doctor of Medical Sciences. Moscow 1974; 40 (in Russian).

[46] Киреева Р.Я. Клещевой риккетсиоз Азии. Вопросы патогенеза, клиники, диагностики и лечения: автореф. дис. … д-ра мед. наук. М. 1974; 40.

[47] Langer H.F., Gawaz M. Interaction of platelets with the vessel wall in atherosclerotic disease. Thromboembolism 2008; 99: 480–486.

[48] Langer H.F., Gawaz M. Platelet-vessel wall interactions in atherosclerotic disease. Thromb Haemost. 2008; 99: 480–486.

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