Role of vagal regulatory mechanisms in ulcerogenesis of perforative pyloroduodenal ulcers

Abstract

Objective. To evaluate the role of psychosomatic and psychosocial factors and alcohol in the mechanisms of ulcerogenesis of perforated pyloroduodenal ulcers.

Materials and methods.  The incidence and volume of treatment of patients with perforated pyloroduodenal ulcers in Kemerovo for 52 years were analyzed. Digestive activity of gastric juice was assessed in case of perforated duodenal ulcer.

Results. It has been established that an increase in the number of patients operated on with perforated pyloroduodenal ulcers correlates with the chronic psycho-emotional overexcitation affecting the vagal regulatory mechanisms of the ulcerogenesis of the perforated pyloroduodenal ulcers. There is no constant direct relationship between the amount of pure alcohol consumption in liters per one adult a year and the incidence rate of disease.

Conclusions. Psychosomatic and psychosocial factors through the vagal regulatory mechanisms increase the aggressiveness of gastric juice and lead to an imbalance between the mechanisms of aggression and the protection of the duodenal mucosa, and, along with alcohol consumption, play an important role in the ulcerogenesis of perforated pyloroduodenal ulcers. The psychogenic factor clearly affects the incidence rate.

Keywords

perforated duodenal ulcer / pyloroduodenal ulcer / ulcerogenesis of perforated ulcers / surgical treatment / morbidity / consumption of pure alcohol

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