Role of connective tissue dysplasia in pathogenesis of diverticular disease

Abstract

Objectives. To conduct a comparative analysis of the role of connective tissue dysplasia in the development of diverticular disease.

Materials and methods. At the screening stage of a single-stage study, clinical, functional, and radiological predictors of connective tissue dysplasia with diagnosed diverticular disease were evaluated. At the second stage of the study, a colonoscopy was performed. The disease was diagnosed by the combination of phenotypic signs of dysmorphic genesis.

Results. At the first stage, in 82 % of cases patients were concerned about their asthenic syndrome. Thirty-two patients with confirmed connective tissue dysplasia underwent colonoscopy. Diverticular disease was diagnosed in 28 patients (89.6 %).

Conclusions. High comorbidity of patients is associated with genetically determined disorders of connective tissue metabolism, manifested by a high frequency of diverticular formation. With a large number of diagnosed phenes, we can predict a rapid progression of diverticular disease. The frequency and severity are due to changes in the mechanical properties of the connective tissue of the submucosal layer.

Keywords

diverticulum / ulcerative colitis / colonoscopy

References

[1] Ardatskaya M.D., Achkasov S.I., Veselov V.V., etc. Diverticular disease: clinical recommendations. Coloproctology 2021; 20: 10–27 (in Russian).

[2] Ардатская М.Д., Ачкасов С.И., Веселов В.В. и др. Дивертикулярная болезнь: клинические рекомендации. Колопроктология 2021; 20: 10–27.

[3] Vorobey A.V., Haji Ismail I.A., Lagodich N.A. et al. Diverticular colon disease: pathogenesis, classification and complications. Medical News 2020; 6 (309): 25–29 (in Russian).

[4] Воробей А.В., Хаджи Исмаил И.А., Лагодич Н.А. и др. Дивертикулярная болезнь ободочной кишки: патогенез, классификация и осложнения. Меди-цинские новости 2020; 6 (309): 25–29.

[5] Nechaeva G.I., Lyalyukova E.A., Rozhkova M.Yu. Connective tissue dysplasia: the main gastroenterological manifestations. Experimental and clinical gastroenterology 2010; 6: 66–69 (in Russian).

[6] Нечаева Г.И., Лялюкова Е.А., Рожкова М.Ю. Дисплазия соединительной ткани: основные гастроэнтерологические проявления. Экспериментальная и клиническая гастроэнтерология 2010; 6: 66–69.

[7] Minushkin O.N., Kruchinina M.A., Altukhova E.I., Yu.E. Tugova Diverticular colon disease: diagnosis, treatment, prevention of complications. Medical Council 2022; 6: 109–115 (in Russian).

[8] Минушкин О.Н., Кручинина М.А., Алтухова Е.И., Тугова Ю.Е. Дивертикулярная болезнь толстой кишки: диагностика, лечение, профилактика ослож-нений. Медицинский совет 2022; 6: 109–115.

[9] Clinical recommendations of the Russian Scientific Medical Society of Therapists on the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia (first revision). Medical Bulletin of the North Caucasus 2018; 1,2 (13): 137–210. DOI: 10.14300/mnnc.2018.13037 (in Russian).

[10] Клинические рекомендации Российского научного медицинского общества терапевтов по диагностике, лечению и реабилитации пациентов с дисплазиями соединительной ткани (первый пересмотр). Медицинский вестник Северного Кавказа 2018; 1,2 (13): 137–210. DOI: 10.14300/mnnc.2018.13037.

[11] Rybachkov V.V., Dryazhenkov I.G., Krasilnikova Z.V. et al. Features of the course of diverticular colon disease. Infections in surgery 2019; 2–3: 30–32 (in Russian).

[12] Рыбачков В.В., Дряженков И.Г., Красильникова З.В. и др. Особенности течения дивертикулярной болезни толстой кишки. Инфекции в хирургии 2019; 2–3: 30–32.

[13] Strelkov N.S., Kildiyarova R.R., Sharaev P.N., Ishmametyev I.L. Connective tissue in children with pathology: monograph. Edited by R.R. Kildiyarova. Izhevsk 2011; 210 (in Russian).

[14] Стрелков Н.С., Кильдиярова Р.Р., Шараев П.Н., Ишмаметьев И.Л. Соединительная ткань у детей при патологии: монография. Под ред. Р.Р. Кильдияровой. Ижевск 2011; 210.

[15] Butolin E.G., Smetanin M.Yu., Druk I.V., Nechaeva G.I., Loginova E., Lyalyukova E.A., Vershinina M.V., Chernyshova T.E., Kononova N.Yu., Styazhkina S.N., Maslova I.S., Kildiyarova R.R. Particular issues of connective tissue dysplasia. Edited by T.E. Chernyshova. Izhevsk 2022; 97 (in Russian).

[16] Бутолин Е.Г., Сметанин М.Ю., Друк И.В., Нечаева Г.И., Логинова Е., Лялюкова Е.А., Вершинина М.В., Чернышова Т.Е., Кононова Н.Ю., Стяжкина С.Н., Маслова И.С., Кильдиярова Р.Р. Частные вопросы дисплазии соединительной ткани. Под ред. Т. Е. Чернышовой. Ижевск 2022; 97.

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