Antitumor activity of solution of natural substance G-01 at the example of sarcoma M-1 when using adjuvant

F. Z. Mirsaeva; Rustam M. Garaishin; Sh. R. Kzyrgalin; R. R. Kitapova; D. A. Kostromina; D. R. Garaishina; T. R. Zaleev

doi:10.17816/pmj403146-151

Perm Medical Journal ›› 2023, Vol. 40 ›› Issue (3) :146 -151. DOI: 10.17816/pmj403146-151

Biology and experimental medicine

research-article

Antitumor activity of solution of natural substance G-01 at the example of sarcoma M-1 when using adjuvant

Author information +

Bashkir State Medical University

Republican Clinical Oncological Dispensary

MD, PhD, Professor of the Department of Surgical Dentistry

Candidate of Medical Sciences, Assistant, Department of Oncology with Courses of Oncology and Pathological Anatomy

Candidate of Pharmacological Sciences, Associate Professor, Department of Pharmacology with Course of Clinical Pharmacology

oncologist

fourth-year student, Pediatric Faculty

fourth-year student, Medical Faculty

Show less

History +

PDF

Abstract

Objective. To study the properties of the G-01 solution with an aluminum hydroxide-based adjuvant singly injected, while changing the concentration of the solution.

Materials and methods. The model of a transfused tumor (Sarcoma M-1) shows the antitumor activity of various concentrations of a solution of natural origin G-01 with the presence of an adjutant.

Results. The prospect of using G-01 solution in medicine as a preventive agent was established. To study the properties of a solution of G-01 with an adjuvant based on aluminum hydroxide singly injected, we found while changing the concentration of the solution that an immune response of different intensity can be induced to the same antigen, depending on the dose and multiplicity of the administered antigen.

Conclusions. In our study, which investigated the effect of G-01 solution on the body of mongrel albino white rats of the "Wistar" line in different concentrations, an optimal 15 % concentration of G-01 solution was found to have a pronounced effect on the immune system, causing the greatest antitumor activity.

Keywords

G-01 / transfused tumor / sarcoma M-1 / adjuvant

Cite this article

Download citation ▾

F. Z. Mirsaeva, Rustam M. Garaishin, Sh. R. Kzyrgalin, R. R. Kitapova, D. A. Kostromina, D. R. Garaishina, T. R. Zaleev. Antitumor activity of solution of natural substance G-01 at the example of sarcoma M-1 when using adjuvant. Perm Medical Journal, 2023, 40(3): 146-151 DOI:10.17816/pmj403146-151

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Trisha Greenhalgh the basics EVIDENCE – BASED MEDICINE Translated from English. Edited by akad. RAS I.N. Denisova, K.I. Saitkulova, V.P. Leonova. 4th edition, revised and expanded 2018.

[2]	Chereshnev V.A., Rodionov S.Yu., Cherkasov V.A., Malyutina N.N., Orlov O.A. Alpha-fetoprotein. Yekaterinburg: Ural Branch of the Russian Academy of Sciences 2004; 376 (in Russian).

[3]	Черешнев В.А., Родионов С.Ю., Черкасов В.А., Малютина Н.Н., Орлов О.А. Альфа-фетопротеин. Екатеринбург: УрО РАН 2004; 376.

[4]	Kokorin I.N., Pytsky V.I. Adjuvants. Big medical encyclopedia: in 30 t. / ch. ed. B.V. Petrovsky. 3rd ed. Moscow: Soviet Encyclopedia, 1974; 1: A – Antibiosis: 576 (in Russian).

[5]	Кокорин И.Н., Пыцкий В.И. Адъюванты. Большая медицинская энциклопедия: в 30 т. Гл. ред. Б.В. Петровский. 3-е изд. М.: Советская энциклопедия 1974; 1: А – Антибиоз: 576.

[6]	Khaitov R.M., Ignatieva G.A., Sidorovich I.G. Immunology. Moscow: Medicine 2000; 432 (in Russian).

[7]	Хаитов Р.М., Игнатьева Г.А., Сидорович И.Г. Иммунология. М.: Медицина 2000; 432.

[8]	Yarilin A.A. Fundamentals of Immunology: Textbook. Moscow: Medicine 1999; 608 (in Russian).

[9]	Ярилин А.А. Основы иммунологии: учебник. М.: Медицина 1999; 608.

[10]	Devita V., Lawrence T., Rosenberg S. Cancer: principles & practice of oncology: primer of the molecular biology of cancer. Medicine 2018; 30 December.

[11]	Khaitov R.M., Pinegin B.V., Yarilin A.A. Guidelines for clinical immunology. Moscow: GEOTAR-Media 2009; 352 (in Russian).

[12]	Хаитов Р.М., Пинегин Б.В., Ярилин А.А. Руководство по клинической иммунологии. М.: ГЭОТАР-Медиа 2009; 352.

[13]	Mail D. Immunology. Translated from English. Moscow: Logosphere 2007; 568 (in Russian).

[14]	Мейл Д. Иммунология: пер. с англ. М.: Логосфера 2007; 568.

[15]	Treshchalina E.M. Antitumor activity of substances of natural origin. Moscow: LLC Practical medicine 2005; 270 (in Russian).

[16]	Трещалина Е.М. Противоопухолевая активность веществ природного происхождения. М.: Практическая медицина 2005; 270.

[17]	Kozlov V.G., Ozherelkov S.V., Sanin A.V., Kozhevnikova T.N. Adjuvants in modern medicine and veterinary. Zh Mikrobiol Epidemiol Immunobiol. 2014; 1: 91–101 (in Russian).

[18]	Kozlov V.G., Ozherelkov S.V., Sanin A.V., Kozhevnikova T.N. Adjuvants in modern medicine and veterinary. Zh Mikrobiol Epidemiol Immunobiol. 2014; 1: 91–101.

[19]	Models and methods of experimental oncology. Edited by A.D. Timofeevsky. Moscow, Medgiz 1960; 246 (in Russian).

[20]	Модели и методы экспериментальной онкологии. Под ред. А.Д. Тимофеевского. М.: Медгиз, 1960; 246.

[21]	Guide to adjuvants in vaccines for human use (in Russian).

[22]	Руководство по адъювантам в вакцинах для использования человеком.

[23]	Gavin A.L., Hube K., Duong B., Ota T., Martin S., Boytler B., Nemazy D. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. The science 2006; 314 (5807): 1936–1938.