Correlation between type 2 diabetes mellitus and pancreatic steatosis

Abstract

Objective. To study the features of endocrine function in non-alcoholic fatty disease of the pancreas in patients with chronic pancreatitis in remission.

Materials and methods. There were examined 62 patients with chronic pancreatitis without exacerbation, who were admitted to the day hospital department of the City Clinical Hospital № 9 (Izhevsk). The data of laboratory and instrumental research methods, the features of the pancreatic endocrine function in patients with chronic pancreatitis, accompanied by fatty degeneration of the organ were analyzed.

Results. Pancreatic steatosis was detected in 80.8 % of cases in patients with chronic pancreatitis in remission with metabolically complicated obesity. Violation of endocrine function was diagnosed in 19.3 % of cases. In the presence of insulin resistance, 6 (16.7 %) of the examined patients were diagnosed type 2 diabetes for the first time. At high insulin levels, 4 (6.5 %) patients had no changes in the indicators of fasting sugar.

Conclusions. All patients with increased insulin resistance and metabolically complicated obesity require a comprehensive clinical and laboratory-instrumental study for the early detection of non-alcoholic fatty pancreatic disease. When establishing the signs of fatty degeneration of the pancreas, dispensary observation as well as prophylactic and therapeutic measures are necessary to prevent the development of type 2 diabetes mellitus.

Keywords

pancreatic steatosis / chronic pancreatitis / obesity / insulin resistance

References

[1] Zvenigorodskaya L.A., Khachaturian N.E. Functional and clinical and morphological changes in the pancreas in metabolic syndrome. Consilium Medicum. 2016; 18 (8): 51–58 (in Russian).

[2] Звенигородская Л.А., Хачатурян Н.Э. Функциональные и клинико-морфологи¬чес¬кие изменения поджелудочной железы при метаболическом синдроме. Consilium Medicum 2016; 18 (8): 51–58.

[3] Afanasiev Yu.I., Kuznetsov S.L., Yuri¬na N.A. Hystology, cytology and embryology. Moscow.: Medicine, 2004; 768 (in Russian).

[4] Афанасьев Ю.И., Кузнецов С.Л., Юрина Н.А. Гистология, цитология и эмбриология. М.: Медицина 2004; 768.

[5] Maksimov V.A., Dalidovich K.K., Fedoruk A.M., Morozkina T.S., Kulikov A.G. Dideases of civilization: systemic metabolic lesions. M.: Adamant Publishing House 2020; 672 (in Russian).

[6] Максимов В.А., Далидович К.К., Федорук А.М., Морозкина Т.С., Куликов А.Г. Болезни цивилизации: системные метаболические поражения. М.: Издательство «АдамантЪ» 2020; 672.

[7] Gubergrits N.B., Khristich, Bonda¬ren¬ko O.A. Non-alcoholic fatty pancreatic disease. Doneck: OO «Lebed» 2013; 236 (in Russian).

[8] Губергриц Н.Б., Христич, Бондаренко О.А. Неалкогольная жировая болезнь поджелудочной железы. Донецк: ОО «Лебедь» 2013; 236.

[9] Sas E.I., Kravchuk Yu.A., Efimov O.I. Obesity: a view of a gastroenterologist and options for drug treatment. Almanac of Clinical Medicine 2015; 1: 24–29.

[10] Сас Е.И., Кравчук Ю.А., Ефимов О.И. Ожирение: взгляд гастроэнтеролога и вариаенты медикаментозного лечения. Альманах клинической медицины. 2015; 1: 24–29.

[11] Smith M.M., MGeen E.J. The clinical significance of pancreatic steatosis. Nat. Rev. Gastroenterol. Hepatol. 2011; 18: 169–177.

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