Antitumor activity of solution of natural substance G-01 at the example of sarcoma M-1 without adjuvant available.

Abstract

Objective. To study the properties of the solution G-01 in a single injection while changing the concentration of the solution.

Materials and methods. The monosaccharide hexose was used as a means of exposing animals. Working code: G-01. The animals were divided into 5 groups: group 1– 10 rats (who received a 10 % solution of G-01 sc, once), group 2 – 10 rats (who received a 15 % solution of G-01 sc, once), group 3 – 10 rats (who received a 20 % solution of G-01 sc, once), group 4 – 10 rats (who received a 25 % solution of G-01 sc, once), group 5 – 10 rats (control group – did not receive G-01 solutions in various concentrations).

Results. During the observation of animals, after transplanting a suspension of tumor cells, the growth of a solid tumor was detected in 100 % of cases in rats of the control group. In the experimental groups, in which 10 % and 25 % G-01 solution was used, the growth of solid tumors was also detected. Moreover, the growth rate and volume of tumors, visually, did not differ in the groups. In rats, who received a 15 % solution of G-01, a tumor developed in 3 out of 10 rats. In rats, who received a 20 % solution of G-01 – in 2 out of 10 rats.

Conclusions. The results of the work carried out prove that the substance of natural origin G-01 is a generator of adaptive immunity for the prevention of the development of the tumor process. In case of the development of the disease, it allows to achieve a tumor regression without the development of serious adverse events affecting the quality of life of animals, that is the main goal of antitumor treatment or prevention of any oncological disease.

Keywords

G-01 / transfused tumor / M-1 sarcoma

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