Clinical and laboratory phenotype of postcovid asthenic syndrome in children of primary school age

Abstract

Objective. To determine the clinical and laboratory features of the postcovid syndrome in children of primary school age.

Materials and methods. The analysis of complaints and anamnesis, somatic and neurological status in 24 children who had a new coronavirus infection was carried out; the results were also analyzed according to the Subjective Asthenia Scale (version for parents), the Quality of Life Assessment Scale (version for children), the Wayne’s questionnaire and scheme, the functional status scale. The concentration of monocytic chemotactic factor in the saliva was determined using enzyme immunoassay.

Results. Most of the children presented astheno-vegetative complaints, which were confirmed by the MFS scores, and the Wayne's questionnaire and scheme. The concentration of monocytic chemotactic protein in the examined cohort of children was 32.48 ± 23.22 pg/ml, with no significant difference by sex. The level of physical functioning by the quality of life scale was significantly higher in boys (100.00 ± 0.00 points) than in girls (82.03 ± 15.46 points, p = 0.02). A correlation was obtained between the salivary monocyte chemotactic protein content and the scores obtained using the Wayne questionnaire and scheme, as well as the MFS and functional status scales.

Conclusions. Vegetative and asthenic syndromes are closely related to the concentration of salivary monocyte chemotactic factor.

Keywords

Postcovid syndrome / autonomic dysfunction / children / monocyte chemotactic protein-1

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