Immunogenetic parameters in children with atopic diseases

Ya. Yu. Illek; I. G. Suetina; N. V. Khlebnikova; E. V. Suslova; M. V. Savinova; E. V. Dudyreva; E. V. Zemtsova

doi:10.17816/pmj40127-33

Perm Medical Journal ›› 2023, Vol. 40 ›› Issue (1) :27 -33. DOI: 10.17816/pmj40127-33

Original studies

research-article

Immunogenetic parameters in children with atopic diseases

Author information +

Kirov State Medical University

Pediatric Clinical Consultative and Diagnostic Center

MD, PhD, Professor, Head of Department of Pediatrics

Candidate of Medical Sciences, Associate Professor, Department of Pediatrics

Candidate of Medical Sciences, Assistant, Department of Pediatrics

Chief Physician

Deputy Chief Physician

pediatrician, allergologist-immunologist

Show less

History +

PDF

Abstract

Objective. To determine the features of the distribution of antigens of the major histocompatibility complex in children of preschool and primary school age with atopic diseases.

Materials and methods. Under observation there were children with a moderate course of the diseases such as atopic dermatitis, atopic dermatitis with concomitant persistent allergic rhinitis, independent persistent allergic rhinitis, atopic bronchial asthma. The patients were identified class I and class II antigens of HLA-complex.

Results. The studies have shown that patients with atopic dermatitis had a high incidence of HLA B15, DRB1*13 and DQB1*0602-8: in patients suffering from atopic dermatitis with concomitant persistent allergic rhinitis – HLA B12, B13 and DQB1 * 01; in patients with independent persistent allergic rhinitis – HLA A10 and DQB1 * 201; in patients with atopic bronchial asthma – HLA B18.

Conclusions. Representation of these antigens of the HLA complex in the tissues was associated with an increase in the risk of atopic diseases by 2.3–4.6 times.

Keywords

Children / atopic diseases / immunogenetic parameters

Cite this article

Download citation ▾

Ya. Yu. Illek, I. G. Suetina, N. V. Khlebnikova, E. V. Suslova, M. V. Savinova, E. V. Dudyreva, E. V. Zemtsova. Immunogenetic parameters in children with atopic diseases. Perm Medical Journal, 2023, 40(1): 27-33 DOI:10.17816/pmj40127-33

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Balabolkin I.I., Lyapunova A.V., Ryleeva I.V. i dr. Bronhial'naya astma u detej. Detskaya allergologiya: rukovodstvo dlya vrachej. Pod red. A.A. Baranova, I.I. Balabolkina. Moscow 2006; 298–371 (in Russian).

[2]	Балаболкин И.И., Ляпунова А.В., Рылеева И.В. и др. Бронхиальная астма у детей. Детская аллергология: руководство для врачей. Под ред. А.А. Баранова, И.И. Балаболкина. М. 2006; 298–371.

[3]	Balabolkin I.I., Grebenyuk V.N., Kudryavceva A.V. Atopicheskij dermatit. Detskaya allergologiya: rukovodstvo dlya vrachej. Pod red. A.A. Baranova, I.I. Balabolkina. Moscow 2006; 424–485 (in Russian).

[4]	Балаболкин И.И., Гребенюк В.Н., Кудрявцева А.В. Атопический дерматит. Детская аллергология: руководство для врачей. Под ред. А.А. Баранова, И.И. Балаболкина. М. 2006; 424–485.

[5]	Zareckaya YU.M. Klinicheskaya immunogenetika. Moscow 1988; 288 (in Russian).

[6]	Зарецкая Ю.М. Клиническая иммуногенетика. М. 1988; 288.

[7]	Illek YA.YU., Zajceva G.A., Galanina A.V. Atopicheskij dermatit u detej rannego vozrasta. Kirov 2007; 124 (in Russian).

[8]	Иллек Я.Ю., Зайцева Г.А., Галанина А.В. Атопический дерматит у детей раннего возраста. Киров 2007; 124.

[9]	Illek YA.YU., Zajceva G.A., Muratova N.G. Atopicheskaya bronhial'naya astma u detej. Kirov 2008; 160 (in Russian).

[10]	Иллек Я.Ю., Зайцева Г.А., Муратова Н.Г. Атопическая бронхиальная астма у детей. Киров 2008; 160.

[11]	Pevnickij L.A. Statisticheskaya ocenka associacij HLA-antigenov s zabolevaniyami. Vestnik akademii medicinskih nauk SSSR 1988; 7: 48–55 (in Russian).

[12]	Певницкий Л.А. Статистическая оценка ассоциаций HLA-антигенов с заболеваниями. Вестник академии медицинских наук СССР 1988; 7: 48–55.

[13]	Svejgaard A., Ryder L.P. HLA and disease associations: detecting the strongest associations. Tissue Antigens 1994; 43: 18–27.

[14]	Terasaki P.I. Microdroplet lymphocyte cytotoxicity: manual of tissue tuping technique. Bethseda 1970; 42–45.

Funding

ФГБОУ ВО Кировский ГМУ Минздрава РоссииFederal State Budgetary Educational Institution of Higher Education Kirov State Medical University of the Ministry of Health of Russia(8-2022-грант)