Effect of comorbid pathology on the outcome of gastric cancer with Krukenberg metastases in a patient of reproductive age: clinical case

Abstract

Objective. To determine the features of the influence of comorbid pathology on the outcome of metastatic gastric cancer in a patient of reproductive age.

Materials and methods. A prospective analysis of a clinical case was carried out on the basis of the Department of Antitumor Drug Therapy № 1 of the Medical Center "Medical City", Tyumen.

Results. The patient’s case, taking into account the data of instrumental examinations, objective examination, general condition of 40 % on the Karnofsky Scale, ECOG-3 (Eastern Cooperative Oncology Group), diagnosis, morphology and complications, was diagnosed as incurable; special methods of antitumor treatment were not indicated. In the current clinical situation, there was used the post-syndrome therapy, prolongation of antiretroviral therapy, examination for searching an infectious agent in the liquor and blood.

Conclusions. Treatment of stage IV gastric cancer is aimed at prolonging the patient's life and improving its quality, stabilizing the disease; its goal is to achieve the same result in terms of quality of life and overall survival as in HIV-negative patients.

Keywords

stomach cancer / HIV infection / immunosuppression / antiretroviral therapy / Krukenberg metastases

References

[1] Kit O.I., Samoylenko N.S., Franzyants E.M. Stomach cancer: modern directions of fundamental research. Modern Problems of Science and education 2019; 4: 136 (in Russian).

[2] Кит О.И., Самойленко Н.С., Франциянц Е.М. Рак желудка: современные направления фундаментальных исследований. Современные проблемы науки и образования 2019; 4: 136.

[3] Ehren K., Hertenstein C., Kümmerle T. Causes of death in HIV-infected patients from the Cologne-Bonn-Cohort. Infection 2014; 42: 135–140.

[4] Rohner E., Wyss N., Heg Z. HIV and human herpesvirus 8 co-infection across the globe: systematic review and meta-analysis. Int J Cancer 2016; 138: 45–54.

[5] Gorbunova V.A., Giyasbeyli S.R., Dadasheva A.E., Mammadov M.K. The frequency of detection of HBsAg in patients with breast, lung and stomach cancer. The World of Viral Hepatitis 2004; 1: 10–11 (in Russian).

[6] Горбунова В.А., Гиясбейли С.Р., Дадашева А.Э., Мамедов М.К. Частота выявления HBsAg у больных раком молочной железы, легкого и желудка. Мир вирусных гепатитов 2004; 1: 10–11.

[7] Gotti D., Raffetti E., Albini L. Survival in HIV-infected patients after a cancer diagnosis in the cART era: Results of an Italian Multicenter Study. PLoS One 2014; 9: 124–132.

[8] Coghill A.E., Shiels M.S., Suneja G., Engels E.A. Elevated cancer-specific mortality among HIV-infected patients in the United States. J Clin Oncol 2015; 33: 2376–2383.

[9] Podymova A.S., Rassokhin V.V. HIV and oncology. HIV infection and immunosuppression 2017; 2: 100–103 (in Russian).

[10] Подымова А.С., Рассохин В.В. ВИЧ и онкология. ВИЧ-инфекция и иммуносупрессии 2017; 2: 100–103.

[11] Nekrasova A.V. Malignant neoplasms in HIV-infected patients. Malignant tumors 2016; 4: 20 (in Russian).

[12] Некрасова А.В. Злокачественные ново-образования у ВИЧ-инфицированных пациентов. Злокачественные опухоли 2016; 4: 20.

[13] Bulatova I.A., Shevlyukova T.P., Shchekotova A.P., Krivtsov A.V. The presence of CAT genetic markers indicates an accelerated rate of progression of liver fibrosis in patients with chronic hepatitis. Experimental and Clinical Gastroenterology 2021; 189: 39–43 (in Russian).

[14] Булатова И.А., Шевлюкова Т.П., Щекотова А.П., Кривцов А.В. Наличие генетических маркеров CAT свидетельствует об ускоренных темпах прогрессирования фиброза печени у больных хроническим гепатитом. Экспериментальная и клиническая гастроэнтерология 2021; 189: 39–43.

[15] Bulatova I.A., Shevlyukova T.P., Shchekotova A.P., Krivtsov A.V. Genetic profile of patients with chronic hepatitis C. Pathological Physiology and Experimental Therapy 2022; 66: 35–43 (in Russian).

[16] Булатова И.А., Шевлюкова Т.П., Ще-котова А.П., Кривцов А.В. Генетический профиль больных хроническим гепатитом С. Патологическая физиология и экспериментальная терапия 2022; 66: 35–43.

[17] Tajibov S.N., Polikarpova S.B., Kochoyan T.M., Kolerev A.S., Kerimov R.A., Berishvili A.I. Metastases of gastric cancer in the ovaries. Survival and prognostic factors. Tumors of the female reproductive system 2016; 4: 57–62 (in Russian).

[18] Таджибов С.Н., Поликарпова С.Б., Кочоян Т.М., Ожерельев А.С., Керимов Р.А., Беришвили А.И. Метастазы рака желудка в яичники. Выживаемость и факторы прогноза. Опухоли женской репродуктивной системы 2016; 4: 57–62.

[19] Zykova T.A. Some medical and statistical indicators of the prevalence of HIV infection among cancer patients. Malignant tumors 2017; 1: 170 (in Russian).

[20] Зыкова Т.А. Некоторые медико-статистические показатели распространенности ВИЧ-инфекции среди онкологических больных. Злокачественные опухоли 2017; 1: 170.

[21] Semashko O.G. HIV infection and the risk of developing malignant tumors. New Science: Strategies and Vectors of Development 2016; 3: 58 (in Russian).

[22] Семешко О.Г. ВИЧ-инфекция и риск развития злокачественных опухолей. Новая наука: Стратегии и векторы раз-вития 2016; 3: 58.

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