Modeling of bleeding from varicose vein of esophagus in a laboratory animal

Abstract

Objective. To develop an accessible, easily reproducible, functional method for modeling bleeding from varicose veins of the esophagus based on the body of a laboratory animal.

Materials and methods. The work is based on an experiment carried out in the operating room of the vivarium of Ryazan State Medical University using laboratory animals – 12 domestic pigs of the Large White breed.

Results. In 10 cases out of 12, it was possible to successfully form changes in the animal's body, allowing to provoke bleeding from the dilated veins of the esophagus, damaging them with biopsy forceps during fibroesophagoscopy.

Conclusions. Creation of an experimental model of bleeding from varicose veins of the esophagus in the body of a domestic pig by dosed clamping of the hepato-duodenal ligament with a plastic clamp, which was followed by subsequent damage of the esophageal veins with biopsy forceps during fibroesophagoscopy, is technically feasible, reliable, and the model itself is quite functional.

Keywords

varicose veins / esophagus / simulation on animals

References

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Funding

Рязанский государственный медицинский университет им. акад. И.П. Павлова Минздрава РоссииRyazan State Medical University named after Academician I.P. Pavlov of the Ministry of Health of Russia

RIGHTS & PERMISSIONS

Budarev V.N., Chekushin A.A.