Manifestations of epidemic process of tuberculosis among HIV-infected patients and dependence of infection frequency on immunodeficiency level and HIV viral load

Abstract

Objective. To assess the manifestations of the epidemic process of tuberculosis (TB) in HIV-infected persons and the frequency of infection depending on the level of immunodeficiency and viral load.

Materials and methods. The epidemiological manifestations of TB incidence among HIV-infected and HIV-negative population of the Perm Region for 2014–2019 were studied. The frequency of TB in HIV-infected patients was determined depending on the level of immunodeficiency (96 patients) and viral load (61 patients).

Results. On average, the incidence of TB among HIV-infected persons was by 36 times higher than that of noninfected persons. Among those infected and noninfected with HIV, TB was registered significantly more often among adults, and mainly men. The incidence of TB among HIV-infected persons is higher among urban population, while HIV-negative – among rural residents. The incidence of TB in HIV-infected persons increases with an increase in the immunodeficiency and viral load.

Conclusions. Persons with HIV infection are at risk for TB. The incidence of TB in HIV-infected persons increases with an increase in immunodeficiency and viral load.

Keywords

HIV-infected persons / indicators of immunodeficiency and viral load / tuberculosis / manifestations of epidemic process

References

[1] Getahun H., Gunneberg C., Granich R., Nunn P. HIV infection-associated tuberculosis: the epidemiology and the response. Clin Infect Dis 2010; 50: 201-207.

[2] Getahun H., Gunneberg C., Granich R., Nunn P. HIV infection-associated tuberculosis: the epidemiology and the response. Clin Infect Dis 2010; 50: 201–207.

[3] Zimina V.N., Mikova O.E., Varetskaya T.A. et al. Detection of tuberculous mycobacteria in sputum and intensity of bacillary excretion in tuberculosis patients with various HIV status. Tuberculosis and lung Diseases 2017; 95 (7): 17-23 (in Russian).

[4] Зимина В.Н., Микова О.Е., Варецкая Т.А. и др. Выявление микобактерий туберкулеза в мокроте и массивность бактериовыделения у больных туберкулезом с различным ВИЧ-статусом. Туберкулез и болезни легких 2017; 95 (7): 17–23.

[5] Mikova O.E., Zhdanova S.N., Sergevnin V.I. et al. High prevalence of genotype B0 / W148 Mycobacterium tuberculosis in HIV infected patients in connection with tuberculosis in Perm and Irkutsk Regions. Bulletin of the East Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences 2016; 1 (5): 142-145 (in Russian).

[6] Микова О.Е., Жданова С.Н., Сергевнин В.И. и др. Высокая распространённость генотипа B0/W148 Mycobacterium tuberculosis у больных ВИЧ-инфекцией, сочетанной с туберкулёзом, в Пермском крае и Иркутской области. Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 2016; 1 (5): 142–145.

[7] Nechaeva O.B. Socially significant infectious diseases posing a biological threat to the population of Russia. Tuberculosis and Lung Diseases 2019; 97 (11): 7-17 (in Russian).

[8] Нечаева О.Б. Социально значимые инфекционные заболевания, представляющие биологическую угрозу населению России. Туберкулёз и болезни лёгких 2019; 97 (11): 7–17.

[9] Galkin V.B., Elenkina Zh.V., Epifantseva N.A. et al. TB / HIV in the Russian Federation. Epidemiology, features of clinical manifestations and treatment results. Moscow: Federal Research Institute for Health Organization and Informatics of the Ministry of Health of the Russian Federation 2017; 52 (in Russian).

[10] Галкин В.Б., Еленкина Ж.В., Епифанцева Н.А. и др. ТБ/ВИЧ в Российской Федерации. Эпидемиология, особенности клинических проявлений и результаты лечения. М.: РИО ЦНИИОИЗ 2017; 52.

[11] Human immunodeficiency virus - medicine. Ed. N.A. Belyakov and A.G. Rakhmanova. Saint Petersburg: Baltic Medical Educational Center 2010; 752 (in Russian).

[12] Вирус иммунодефицита человека – медицина. Под ред. Н.А. Белякова и А.Г. Рахмановой. СПб.: Балтийский медицинский образовательный центр 2010; 752.

[13] Bogoroskaya Е.М., Sinitsin M.V., Belilovsky E.M. и др. Impact of the hIV-InfectIon on the Incidence of tuberculosis structure In the moscow city megapolis. Tuberculosis and Lung Diseases 2016; 3: 3-17 (in Russian).

[14] Богородская Е.М., Синицын М.В., Белиловский Е.М. и др. Влияние ВИЧ-инфекции на структуру показателя заболеваемости туберкулезом в условиях мегаполиса. Туберкулёз и социально значимые заболевания 2016; 3: 3–17.

[15] Kurganova T.Yu., Melnikova T.N., Kovalev N.Yu. и др. Epidemiology of three coinfections: HIV, viral hepatitis and tuberculosis in the Vologda region as a model of infection development in the northwestern federal district. HIV Infection and Immunosuppressive Disorders 2021; 13 (1): 7-16 (in Russian).

[16] Курганова Т.Ю., Мельникова Т.Н., Ковалев Н.Ю. и др. Эпидемиология трех коинфекций: ВИЧ, вирусного гепатита и туберкулеза – в Вологодской области как модель развития инфекций в Северо-Западном федеральном округе. ВИЧ-инфекция и иммуносупрессии 2021; 13 (1): 7–16.

[17] Zagdyn Z.M., Sivacheva I.L., Zverkova E.A., Beltyukov M.V., Sokolovich E.G. Antiretroviral Rolle in tuberculosis prevention among people living with human immunodeficiency virus (retrospective cohort clinical study). Journal Infectology 2018; 10 (1): 89-95 (in Russian).

[18] Загдын З.М., Сивачева И.Л., Зверкова Е.А. Роль антиретровирусной терапии в профилактике туберкулеза среди людей, живущих с вирусом иммунодефицита человека (ретроспективное когортное клиническое исследование). Журнал инфектологии 2018; 10 (1): 89–95.

[19] Girardi E., Sabin C.A., Arminio M.d’ et al. Incidence of Tuberculosis among HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy in Europe and North America. Clin Infect Dis 2005; 41 (12): 1772-1782.

[20] Girardi E., Sabin C.A., Arminio M.d’ et al. Incidence of Tuberculosis among HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy in Europe and North America. Clin Infect Dis 2005; 41 (12): 1772–82.

[21] Hermans S.M., Kiragga A.N., Schaefer P. et al. Incident Tuberculosis during Antiretroviral Therapy Contributes to Suboptimal Immune Reconstitution in a Large Urban HIV Clinic in Sub-Saharan Africa. PLoS One 2010; 5 (2): 1-8.

[22] Hermans S.M., Kiragga A.N., Schaefer P. et al. Incident Tuberculosis during Antiretroviral Therapy Contributes to Suboptimal Immune Reconstitution in a Large Urban HIV Clinic in Sub-Saharan Africa. PLoS One 2010; 5 (2): 1–8.

[23] Pokrovsky V.I., Litvinov V.I., Lovacheva O.V., Lazareva O.L. Tuberculous meningitis. Moscow 2005; 244 (in Russian).

[24] Покровский В.И., Литвинов В.И., Ловачева О.В., Лазарева О.Л. Туберкулезный менингит. М. 2005; 244.

[25] Fenner Lukas, Atkinson Andrew, Boulle Andrew et al. HIV viral load as an independent risk factor for tuberculosis in South Africa: collaborative analysis of cohort studies. Journal of the International AIDS society 2017; 20 (1).

[26] Lange Christoph, van Leth Frank, Sester Martina for the TBnet. Viral Load and Risk of Tuberculosis in HIV Infection. Journal of Acquired Immune Deficiency Syndromes 2016; 71 (2): 51-53.

[27] Lange Christoph, van Leth Frank, Sester Martina for the TBnet. Viral Load and Risk of Tuberculosis in HIV Infection. Journal of Acquired Immune Deficiency Syndromes 2016; 71 (2): 51–53.

RIGHTS & PERMISSIONS

Sergevnin V.I., Tukacheva O.V.