Cellular composition of gastric glands in chronic gastritis among children

Abstract

Objective. To establish the features of the cellular composition of gastric mucosa glands in chronic Hp-associated gastritis among children to improve its diagnostics.

Material and methods. Morphometric analysis of fundal and pyloric gland cell populations was performed in 214 children aged 6–15 years with Hp-associated chronic gastritis. For this purpose, the number of main, parietal, endocrine and additional cells was calculated in the materials of gastrobiopsy of the gastric mucosa, the result was expressed in ‰ (per 1000 epithelial cells).

Results. It was found that as the severity of inflammation in the fundal glands increases, the number of main cells decreases, the number of parietal, accessory and especially endocrine cells grows. In the pyloric glands, a reduction of the parietal pool, a decrease in the population of additional cells and a sharp increase in endocrinocytes is registered. With a decrease in the severity of inflammation, positive changes in the cellular composition of the glands are observed, but its full normalization does not occur 6 months after the course of antihelicobacter therapy. A significant proportion of patients, shows morphological signs of gastric mucosa atrophy, which is associated with inflammation and is uncertain. Its presence does not significantly affect the cellular composition of the gastric glands, and the regression of the inflammatory process is accompanied by a decrease in the degree of atrophy or complete disappearance of signs of the latter.

Conclusions. The addition of a standard study of gastrobioptates with a quantitative morphometric analysis of the cellular composition of the fundal and pyloric glands in chronic gastritis among children objectifies the data of morphological assessment of pathohistological picture of gastric mucosa.

Keywords

Chronic gastritis / gastric glands / cellular composition / children

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Akkuratova-Maksimova I.S., Manyakina O.M., Shkolina O.V.