Correlation between adipocytokine profile and heart rate variability in patients with obesity

Abstract

Objective. The high prevalence of obesity in employable population dictates the necessity for preclinical diagnosis of diseases associated with it, including the study of the autonomic regulation of heart rhythm. The objective was to study the correlations between the adipocytokine profile and heart rate variability in patients with obesity.

Materials and methods. 300 persons were examined, the average age was 46.2 ± 6.4 years; Group 1 was metabolically unhealthy obesity phenotype (MUHOP) – 90 patients; group 2 was obesity without metabolic disorders [Ob(+)MD(-)] (MHOP) – 50 persons; the control group consisted of 100 healthy respondents. We studied the following indices: blood serum adipocytokines: leptin, insulin, resistin, adiponectin. Heart rate variability was studied using Poly-Spectrum Rhythm 2012 computer electrocardiograph.

Results. In the course of the study, decrease in the total heart rate variability and reactivity of the parasympathetic part of the autonomic nervous system in patients from MUHOP group was found, while there were no differences with the control in the MHOP group. It was established that a decrease in the parasympathetic effect on the regulation of heart rhythm is associated with the presence of abdominal obesity, insulin resistance, and an increase in the level of TG, glucose, resistin, and uric acid.

Conclusions. The received relationships between indicators of carbohydrate and lipid metabolism, the level of uric acid and adipocytokines with temporal and spectral characteristics of the autonomic nervous system confirm their contribution to the development of autonomic dysfunction in obese persons.

Keywords

obesity / heart rate variability / adipocytokines

References

[1] Vsemirnaia organizatsiia zdravookhraneniia 2020 Mart, available at: https www who int ru news-room fact-sheets detail obesity-and-overweight (in Russian).

[2] Всемирная организация здравоохранения. 2020. Март, available at: https:// www.who.int/ru/news-room/fact-sheets/detail/ obesity-and-overweight.

[3] Drapkina O.M., Dubolazova U.V. Boitsov S.A. i soavt. Fighting with obesity: the "gold standard" and new horizons. Ratsionalnaia farmakoterapiia v kardiologii 2016; 12 (4): 450–458 (in Russian).

[4] Драпкина О.М., Дуболазова Ю.В., Бойцов С.А. и др. Борьба с ожирением: «золотой стандарт» и новые горизонты. Рациональная фармакотерапия в кардиологии 2016; 12 (4): 450–458.

[5] Kseneva C.I., Borodulina E.V., Trifonova O.U., Udut V.V. Dysregulation of the autonomic nervous system in the mechanisms of metabolic syndrome development. Sibirskii meditsinskii zhurnal 2019; 4: 119–124 (in Russian).

[6] Ксенева C.И., Бородулина Е.В., Трифонова О.Ю., Удут В.В. Вегетативная дизрегуляция в механизмах формирования проявлений метаболического синдрома. Сибирский медицинский журнал 2019; 4: 119–124.

[7] Kratnov A.E., IAkimova A.V., Silkina E.E. Heart rate variability in male patients with metabolic syndrome. Sakharnyi diabet 2013; 1: 15–18 (in Russian).

[8] Кратнов А.Е., Якимова А.В., Силкина Е.Е. Вариабельность ритма сердца у мужчин с метаболическим синдромом. Сахарный диабет 2013; 1: 15–18.

[9] Gorban V.V., Chernoglazov K.S. Features of heart rate variability in young people, associated with body weight. Kubanskii nauchnyi meditsinskii vestnik 2015; 4 (153): 63–68 (in Russian).

[10] Горбань В.В., Черноглазов К.С. Особенности вариабельности ритма сердца у молодых людей, ассоциированные с массой тела. Кубанский научный медицинский вестник 2015; 4 (153): 63–68.

[11] Piestrzeniewicz K. Obesity and heart rate variability in men with myocardial infarction. Cardiol J 2008; 15 (1): 43–49.

[12] Charles L.E., Andrew M.E., Sarkisian K. et al. Associations between insulin and heart rate variability in police officers. Am J Hum Biol 2014; 26: 56–63.

RIGHTS & PERMISSIONS

Shulkina S.G., Smirnova E.N., Laurent E.A., Kolomeets N.Y., Konovalov V.V., Kozmenko O.A., Chernukha T.A.