Importance of determining macro- and microelemental composition of blood in pregnant women with threat of preterm birth

Abstract

Aim. In order to establish the dependence of the threat preterm birth in pregnant women on the concentration of macro- and micronutrients, a comparative analysis of blood was carried out in 92 pregnant women aged 19 to 37 before and after treatment.

Materials and methods. Quantitative elemental analysis of blood serum was performed for 8 elements: Ca, Cu, Fe, K, Mg, Na, Zn, Se using the method of inductively coupled plasma atomic emission spectrometry (ICP MS 7700e, Intertech. Corp., USA).

Results. The conducted macro- and microelements content analysis revealed that during pregnancy, childbirth and perinatal period, a violation of their quantity is of no small importance.

Conclusions. A reliably significant dependence of the threat of abortion, hypoxia, intrauterine growth retardation on the balance of macro- and microelements was noted.

Keywords

Preterm birth / macrocells / microelements / blood test

References

[1] Ахмина Н.И. Значение витаминов и микроэлементов при беременности. Лечащий врач 2005; 10: 12–17.

[2] Башмакова Н.В. Оптимизация клинических исходов преждевременных родов: опыт Уральского федерального округа. StatusPraesens 2014; 6 (23): 13–19.

[3] Вахлова И.В. Микронутриенты для здоровья матери и ребенка. Рос. пед. журн. 2005; 4: 55–59.

[4] Сухих Г.Т., Ходжаева З.С., Донников А.Е. Молекулярно-генетические предикторы эффективности токолитической терапии в пролонгировании беременности при угрожающих преждевременных родах. Акушерство и гинекология 2014; 2: 27–34.

[5] Ткачева О.Н. Макро- и микроэлементный статус при беременности. Дефицит магния и его коррекция при артериальной гипертензии у беременных. М. 2007; 189.

[6] Трошина Е.А. Дефицит микроэлементов во время беременности. Акушерство и гинекология 2009; 1: 7–10.

[7] Хамадьянов У.Р., Таюпова И.М., Хамадьянова А.У. Латентный дефицит железа во время беременности. Вопросы гинекологии, акушерства и перинатологии 2009; 8 (4): 69–74.

[8] Conde-Agudelo A., Romero R. Cervicovaginal fetal fibronectin for the prediction of spontaneous preterm birth in multiple pregnancy: a systematic review and meta-analysis. J Matern Fet Neonat Med 2010; 23 (12): 1365–1376.

[9] Dickey R.P., Xiong X., Gee R.E., Pridjian G. Effect of maternal height and weight on risk of preterm birth in singleton and twin births resulting from in vitro fertilization. Fertil Steril 2012; 97 (2): 349–354.

[10] Norman J.E. et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, doubleblind trial. Lancet 2016; 387.

[11] Romero R. et al. Vaginal progesterone decreases preterm birth ≤ 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM. Ultrasound Obstet Gynecol 2016; 48 (3): 308–317.

[12] Sandeva M., Uchikova E. Frequency and medical social aspects premature birth. Akush Ginekol (Sofiia) 2016; 55 (2): 27–33.

[13] Tazhetdinov E.H., Gagaev Ch.G., Apresyan S.V., Trifonova O.S. Efficiency of modern technology in the management of preterm labor. Bulletin of the Peoples’ Friendship University of Russia. Series: Medicine 2012; 6: 51–56.

[14] Walsh J., Allen V.M., Colford D., Allen A.C. Preterm prelabor rupture of membranes with cervical cerclage: a review of perinatal outcomes with cerclage retention. J Obstet Gynaecol Can 2010; 32: 448–452.

RIGHTS & PERMISSIONS

Abdullaeva N.Y.