Estimation of proinflammatory cytokine and heat shock protein levels in atopic dermatitis

Natalia M. Ivanova; Irina V. Kibalina; Namzil N. Tsybikov

doi:10.17816/pmj36338-42

Perm Medical Journal ›› 2019, Vol. 36 ›› Issue (3) :38 -42. DOI: 10.17816/pmj36338-42

Methods of diagnosis and technologies

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Estimation of proinflammatory cytokine and heat shock protein levels in atopic dermatitis

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Abstract

Aim. To estimate the proinflammatory cytokineI L-17α level, HSP-70 level and autoantibodies to it in pathogenesis of atopic dermatitis (AD) at its exacerbation stage.

Materials and methods. Twenty patients aged 18–35 years were examined; cytokine IL-17α levels, HSP-70 chaperone levels and autoantibodies to it were studied in patients, suffering from typical form of atopic dermatitis at exacerbation stage. Statistical processing of the obtained material was implemented with STATISTICA 6.1 for Windows.

Results. Atopic dermatitis causes chronic inflammatory damage of the skin, the cells are in stress state for a long time that contributes to accumulation of the damaged proteins in them and significant growth of chaperone synthesis.

Conclusions. In the period of active clinical symptomatology, patients with atopic dermatitis demonstrated decrease in blood IL-17α concentration and increase in HSP70 level and autoantibodies to it.

Keywords

IL-17α / heat shock proteins / HSP 70 / atopic dermatitis / autoantibodies

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Natalia M. Ivanova, Irina V. Kibalina, Namzil N. Tsybikov. Estimation of proinflammatory cytokine and heat shock protein levels in atopic dermatitis. Perm Medical Journal, 2019, 36(3): 38-42 DOI:10.17816/pmj36338-42

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