Cortical superficial siderosis is a new MRT-phenomenon in neurological practice: clinical observations and review of literature

Abstract

Cerebral amyloid angiopathy (CAA) is a specific variant of cerebral small vessel disease, associated with high risk of spontaneous intracerebral bleedings, cognitive disorders and hemorrhagic complications of antithrombotic and thrombolytic therapy. One of key markers of CAA is a relatively rare neurovisual phenomenon – cortical superficial siderosis (CSS). Two clinical cases of CAA with CSS are described in the present paper. In the first case, typical CAA complication were observed: intracerebral bleeding and cognitive disorders. In the second case, CAA was symptom-free. Analysis of clinical cases and literature data shows phenotypic heterogeneity of CAA and confirms advisability of routine use of paramagnetic conditions of MRT to examine patients with cerebrovascular disease.

Keywords

cerebral amyloid angiopathy / cortical superficial siderosis / small vessel disease / cognitive disorders / intracerebral hematoma

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RIGHTS & PERMISSIONS

Kulesh A.A., Gorst N.K., Drobakha V.E., Kaileva N.A., Shestakov V.V.