Study of multiple sclerosis pathogenesis as the basis of its target therapy

Abstract

Aim. To study the antigen-presenting ability of B-cells, class IV semaphorin Sema4D (CD100) and CD72 receptor expression in the immune system of patients with multiple sclerosis (MS); to study the interaction between the KIF1B gene polymorphisms and the variants of response to preparation, changing the course of multiple sclerosis in MS patients.

Materials and methods. Patients with the established diagnosis of “Multiple sclerosis” by McDonald criteria 2010 with remitting type of the disease course were examined. Clinical method, psychometric testing, immune-enzyme analysis, immunologic method, PCR technique were used.

Results. Among patients with MS, the antigen-presenting function of B-lymphocytes was changed, semaphorin Sema4D/CD100 expression level on T-lymphocyte membrane was elevated, CD72 receptor expression on B-lymphocyte membrane was decreased. The studied phenomena are associated with a number of clinical characteristics that permits to consider them to participate in the pathogenesis of this disease.

Conclusions. Pathogenetic characteristics of multiple sclerosis are added by new data, which can be the targets for therapeutic strategies in the form of using anti-Sema4D- and anti-B-lymphocytic antibodies as immunomodulating therapy of MS.

Keywords

Multiple sclerosis / B-lymphocytes / semaphorin Sema4D / KIF1B gene

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RIGHTS & PERMISSIONS

Baidina T.V., Kuklina E.M., Selyanina N.V., Trushnikova T.N., Sursyakova N.V., Danchenko I.Y., Arbuzova E.E.