SIGNIFICANCE OF MATRIX METALLOPROTEINASE-9 IN DEVELOPMENT OF COGNITIVE DISORDERS DURING ACUTE PERIOD OF ISCHEMIC STROKE

D P Kalinsky; Yu V Khlystov; P P Kalinsky; O S Golovina

doi:10.17816/pmj34549-54

Perm Medical Journal ›› 2017, Vol. 34 ›› Issue (5) :49 -54. DOI: 10.17816/pmj34549-54

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SIGNIFICANCE OF MATRIX METALLOPROTEINASE-9 IN DEVELOPMENT OF COGNITIVE DISORDERS DURING ACUTE PERIOD OF ISCHEMIC STROKE

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Abstract

Aim. To study the correlation between matrix metalloproteinase-9 (MMP-9) serum concentration and manifestation of cognitive disorders in patients with ischemic stroke (IS) in its acute period. Materials and methods. Ninety four patients with IS in the pool of the left medial cerebral artery were examined; MMP-9 concentration was determined within the days 1-2 of the disease. Neuropsychological testing to assess the degree of manifestation of cognitive disorders was carried out within the days 7 and 18-21. Results. In the group of patients with high MMP-9 content compared to the control (353.7 ± 17.4 and 96.29 ± 11.37 ng/ml) ( p < 0.05), significantly more marked cognitive disorders were diagnosed. Conclusions. A direct correlation between the level of MMP-9 content and the degree of manifestation of cognitive disorders was stated, allowing to consider MMP-9 as a prognostic marker of the development of postinsult cognitive disorders.

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Acute period of ischemic stroke / cognitive disorders / matrix metalloproteinase-9

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D P Kalinsky, Yu V Khlystov, P P Kalinsky, O S Golovina. SIGNIFICANCE OF MATRIX METALLOPROTEINASE-9 IN DEVELOPMENT OF COGNITIVE DISORDERS DURING ACUTE PERIOD OF ISCHEMIC STROKE. Perm Medical Journal, 2017, 34(5): 49-54 DOI:10.17816/pmj34549-54

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