EPIDEMIOLOGICAL ASSESSMENT OF RISK FACTORS FOR PREVALENCE OF ANTIBIOTIC-RESISTANT STRAINS OF UPPER AIRWAYS AND ENT-ORGANS INFECTIOUS PATHOGENS IN CHILDREN
A A Shishmakov , D S Kolesnik , Zh G-K Toleuova , V V Kolodzhieva , E A Lebedeva , A E Goncharov , L P Zueva , P V Nacharov , S V Verbolova , I A Dveirina , L P Makhotina
Perm Medical Journal ›› 2017, Vol. 34 ›› Issue (4) : 54 -59.
EPIDEMIOLOGICAL ASSESSMENT OF RISK FACTORS FOR PREVALENCE OF ANTIBIOTIC-RESISTANT STRAINS OF UPPER AIRWAYS AND ENT-ORGANS INFECTIOUS PATHOGENS IN CHILDREN
Aim. To give epidemiological assessment of potential risk factors for prevalence of antibiotic resistant strains of upper airways and ENT-organs infectious pathogens in children. Materials and methods. The study included children (165 persons) aged 1 to 17years, who asked for ambulatory-polyclinic medical care in connection with upper airways and ENT-organs diseases and formed the group of “cases” (75 persons) - patients, colonized by Streptococcus spp. and Staphylococcus aureus strains with antibiotic resistance not less than one of three classes (beta-lactams, macrolides, lincosamides) and the control group (90 persons) - patients without the facts of colonization by antibiotic-resistant strains of the studied microorganisms. During doctor’s reception, parents of all patients were surveyed. Results. According to the results of a survey carried out, there was estimated connection of 18 potential risk factors with carriage of antibiotic-resistant strains. Pneumococcal vaccination in the investigated population was a factor, rendering preventive effect on the colonization rate of antibiotic-resistant strains Streptococcus spp. and Staphylococcus aureus ( OR = 0,40 [95 %DI 0,19-0,86]). At the same time, no ties between colonization by antibiotic-resistant microorganisms and risk factors, connected with previous use of antibiotics, especially without doctor’s administration, was noted. Conclusions. Vaccination with pneumococcal vaccines in the studied population is a factor, controlling prevalence of resistance to antimicrobial drugs
Streptococcus spp / Staphylococcus aureus / Antibioticresistance / respiratory diseases / Streptococcus spp. and Staphylococcus aureus / risk factors
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Shishmakov A.A., Kolesnik D.S., Toleuova Z.G., Kolodzhieva V.V., Lebedeva E.A., Goncharov A.E., Zueva L.P., Nacharov P.V., Verbolova S.V., Dveirina I.A., Makhotina L.P.
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