ASSESSMENT OF POTENTIAL ROLE OF PATIENTS WITH ASSOCIATED HIV-INFECTION AND TUBERCULOSIS AS A SOURCE OF TUBERCULOUS INFECTION

Abstract

Aim. To estimate the potential role of patients with associated HIV infection and tuberculosis as a source of tuberculous infection as compared with monotuberculosis patients. Materials and methods. Epidemiological danger of patients was assessed by the degree of bacterioexcretion massiveness and its share in the structure of M. tuberculosis of virulent genotype Beijing. Massiveness of bacterioexcretion was studied by the results of luminescent microscopy and bacteriological analysis of phlegm, genotyping - with test-system “Amplitub-Beijing” and method MIRU-VNTR. Results. It was established that in spite of the lesser quantity of M.tuberculosis, excreted by patients with HIV-infection associated with tuberculosis, as compared to patients with monotuberculosis, coinfected patients more often discharge high-virulent genotype Beijing, therefore, may be more epidemiologically dangerous as a source of tuberculous infection. Conclusions. According to the results of bacteriological study of the phlegm by means of dense nutrient medium, in patients with associated HIV infection and tuberculosis lesser massiveness of M. tuberculosis excretion than in patients with tuberculosis without HIV infection was revealed. In the structure of M. tuberculosis, isolated from patients with associated HIV-infection and tuberculosis, the share of genotype Beijing was more than 90 %, from patients with tuberculosis without HIV-infection - only 70 %.

Keywords

HIV infection associated with tuberculosis / massiveness of M. tuberculosis genotype excretion

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RIGHTS & PERMISSIONS

Sergevnin V.I., Sarmometov E.V., Zimina V.N., Mikova O.E., Varetskaya T.A.