BLOOD NEUROTROPHINS IN CHRONIC CEREBRAL ISCHEMIA

S V Tsepilov; Yu V Karakulova

doi:10.17816/pmj33660-65

Perm Medical Journal ›› 2016, Vol. 33 ›› Issue (6) :60 -65. DOI: 10.17816/pmj33660-65

Articles

research-article

BLOOD NEUROTROPHINS IN CHRONIC CEREBRAL ISCHEMIA

Author information +

History +

PDF

Abstract

Aim. To study the emotional and cognitive statuses, quality of life as well as quantitative content of neurotrophic factors such as blood serum BDNF, CNTF in patients with stages I and II chronic cerebral ischemia (CCI). Materials and methods. Seventy three patients (13 men and 60 women with a mean age of 63 ± 6 years) with CCI were examined and treated at the Health Resort “Klyuchi”. All of them underwent psychometric testing and determination of serum neurotrophic factors (brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF). Results. Cognitive and emotional disorders of different degrees and decrease in quantitative blood serum BDNF content (386,4 ± 107 pg/ml) was revealed. A mean index of CNTF was 125 ± 10,5 pg/ml, that did not differ from the control figures; BDNF level correlated with the degree of cognitive disorders and manifestation of neurological deficit. Conclusions. Among CCI patients there was observed a reduction in cognitive functions connected with deficit of cerebral neurotrophic factor BDNF in blood, which occurs, probably, as a result of decrease in cerebral activity in conditions of depleted cerebral blood flow.

Keywords

Chronic cerebral ischemia / cognitive disorders / cerebral neurotrophic factor

Cite this article

Download citation ▾

S V Tsepilov, Yu V Karakulova. BLOOD NEUROTROPHINS IN CHRONIC CEREBRAL ISCHEMIA. Perm Medical Journal, 2016, 33(6): 60-65 DOI:10.17816/pmj33660-65

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Гомазков О.А. Нейротрофическая регуляция и стволовые клетки мозга. М: Икар 2006; 332.

[2]	Гусев Е.И., Скворцова В.И. Ишемия головного мозга. М.: Медицина 2001; 328.

[3]	Ковальчук В.В. Терапевтические возможности улучшения когнитивных функций, психоэмоционального состояния и качества жизни пациентов после инсульта. Журнал неврологии и психиатрии им. С.С. Корсакова 2015; 12: 92-98.

[4]	Каракулова Ю.В., Амирахова Л.Ш. Роль нейротрофинов в восстановлении после ишемического инсульта под влиянием нейропротекторной терапии. Неврологический журнал 2014; 6: 36-39.

[5]	Сосудистые заболевания нервной системы. Под ред. Е.В. Шмидта. М.: Медицина 1975; 284.

[6]	Федин А.И. Современные аспекты нейропротекции и нейропластичности: от теории к практике. Инновационные подходы к нейропротекции: материалы науч.-практ. конф. М. 2012.

[7]	Шляхто Е.В., Баранцевич Е.Р., Щербак Н.С., Галагудза М.М. Молекулярные механизмы формирования ишемической толерантности головного мозга (Обзор литературы. Часть 2). Вестник Российской академии медицинских наук 2012; 7: 20-29.

[8]	Яхно Н.Н., Захаров В.В. Когнитивные и эмоционально-аффективные нарушения при дисциркуляторной энцефалопатии. Российский медицинский журнал 2002; 10 (12-13): 28-37.

[9]	Grigsby J., Kaye K., Shertterly S.M. et al. Prevalence of disorders of executive cognitive functioning among elderly. Neuroepidemilogy 2002; 21: 213-220.

[10]	Rockwood K., Wentzel C., Hachinscki V. et al. Prevalence and outcomes of vascular cognitive impairment. Neurology 2000; 54: 447-451.

[11]	Tyler W.J., Perrett S., Pozzo-Miller L.D. The role of neurotrophins in neurotransmitter release. Neuroscientist 2002; 8: 524-531.

[12]	Webster M.J. et al. BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex. Dev Brain Res 2002; 139 (2): 139-150.