POLYMORPHISM OF VITAMIN D RECEPTOR (VDR) GENE IN SAMPLING OF EUROPEAN RUSSIA AND PRIURALIYE POPULATION

A I Kozlov; G G Vershubskaya; M A Negasheva

doi:10.17816/pmj33560-66

Perm Medical Journal ›› 2016, Vol. 33 ›› Issue (5) :60 -66. DOI: 10.17816/pmj33560-66

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POLYMORPHISM OF VITAMIN D RECEPTOR (VDR) GENE IN SAMPLING OF EUROPEAN RUSSIA AND PRIURALIYE POPULATION

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Abstract

Aim. To assess the genotype frequencies of VDR BsmI (rs1544410) and FokI (rs10735810) in ethnic Russian population and in different groups of the population of Volgo-Kamsky region and Priuraliye. Materials and methods. Samplings of Russians of the European part of RF ( n = 96) and Eastern Finns including Komi-Permyaks ( n = 71), Komis ( n = 190) and Udmurts ( n = 86) were examined. Genotype frequencies were determined using the method of PCR-amplification. Results. Russians differ for the inhabitants of Moscow (without taking into account ethnic origin) by the distribution of VDR FokI ( p = 0,09001), but not BsmI. Eastern Finns in the regions of their historical residence do not differ by VDR FokI and BsmI, but they differ from Russians by BsmI frequencies ( p = 0,0856). Conclusions. The obtained results agree with the assumption about the specificity of VDR allel frequencies in different ethnic groups.

Keywords

VDR / FokI / BsmI / Vitamin D / Vitamin D receptor / VDR / FokI / BsmI / bone tissue

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A I Kozlov, G G Vershubskaya, M A Negasheva. POLYMORPHISM OF VITAMIN D RECEPTOR (VDR) GENE IN SAMPLING OF EUROPEAN RUSSIA AND PRIURALIYE POPULATION. Perm Medical Journal, 2016, 33(5): 60-66 DOI:10.17816/pmj33560-66

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References

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[1]	Атрушкевич В.Г., Зяблицкая М.С. Полиморфизм гена VDR и пародонтит, аvailable at: http://www.stomport.ru/articlepro_show_id_337.

[2]	Бабенко С.А., Алифарова В.М., Орлова Ю.Ю., Пузырев В.П. Связь аллельных вариантов гена VDR с рассеянным склерозом. Бюллетень сибирской медицины, 2008, 5: 40-46.

[3]	Беневоленская Л.И., Финогенова С.А. Генетика остеопороза. II. Изучение роли гена рецептора витамина D. Остеопороз и остеопатии 1999; 3: 28-31.

[4]

Борисова Н.А., Хуснутдинова Э.К., Хидиятова И.М., Абулгатина А.С., Мирсаев Т.Р., Хусаинова Р.И., Кутуев И.А. Исследование полиморфизмов Spl (1546G>T) гена коллагена 1 и Fokl (3663Т>С) гена рецептора витамина D у больных сирингомиелией. Журнал неврологии и психиатрии им. С.С. Корсакова 2007; 9: 60-66.

[5]	Козлов А.И., Вершубская Г.Г., Атеева Ю.А., Орр П., Лакомб Л. Ассоциация полиморфизма гена рецептора витамина D с антропометрическими показателями в группе этнических коми. Экологическая генетика 2013; 11 (2): 41-49.

[6]	Кочеткова Е.А., Бубнов О.Ю., Васильева Т.Г., Белых О.А. Генетические аспекты остеопороза. Тихоокеанский медицинский журнал 2005; 2: 14-17.

[7]	Мякоткин В.А., Крылов М.Ю., Гусева И.А., Четина Е.В., Торопцова Н.В., Никитинская О.А., Самаркина Е.Ю., Беневоленская Л.И. Молекулярно-генетическое тестирование предрасположенности к остеопорозу у женщин в менопаузе в Москве. Научно-практическая ревматология 2011; 2: 15-20.

[8]	Рудко А.А., Кондратьева Е.И., Янкина Г.Н., Лошкова Е.В., Пузырев В.П. Полиморфизм генов - модификаторов иммунного ответа: влияние на развитие целиакии и варианты ее клинического течения в томской популяции. Молекулярная биология 2008; 42(1): 42-49.

[9]	Спиричев В.Б. О биологических эффектах витамина D. Педиатрия 2011; 90 (6): 113-119.

[10]

Тагиева А.Н., Сметник В.П., Сухих Г.Т., Крылов М.Ю., Греченко А.В., Мякоткин В.А., Беневоленская Л.И. Изучение роли генов рецептора витамина D (VDR), α-рецептора эстрогенов (ESRα) и α-1-цепи коллагена 1-го типа (COLIAI) в заболеваемости остеопорозом у женщин в постменопаузе. Медицинская генетика 2005; 4 (2): 90-95.

[11]	Ших Е.В., Милотова Н.М. Роль полиморфизма гена VDR, кодирующего рецептор витамина D, в патогенезе артериальной гипертонии. Биомедицина 2009; 1: 55-67.

[12]	Ames S.K., Ellis K.J., Gunn S.K., Copeland K.C., Abrams S.A. Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children. J Bone Mineral Res 1999; 14 (5): 740-746.

[13]	Butler M.W., Burt A., Edwards T.L., Zuchner S., Scott W.K., Martin E.R. Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet 2011; 75 (2): 201-210.

[14]	Colombini A., Cauci S., Lombardi G., Lanteri P., Croiset S., Brayda-Bruno M., Banfi G. Relationship between vitamin D receptor gene (VDR) polymorphisms, vitamin D status, osteoarthritis and intervertebral disc degeneration. J Steroid Biochem Mol Biol 2013; 138: 24-40.

[15]	Fang Y., van Meurs J.B.J., Rivadeneira F., van Schoor N.M., van Leeuwen J.P.T., Lips P., Pols H.A.P., Uitterlinden A.G. Vitamin D receptor gene haplotype is associated with body height and bone size. J Clin Endocrinol Metabol 2007; 92(4): 1491-1501.

[16]	Filus A., Trzmiel A., Kuliczkowska-Płaksej J., Tworowska U., Jedrzejuk D., Milewicz A., Medras M. Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome. Aging Male 2008; 11 (3): 134-139.

[17]	Gang Q., Dong Z., Zeng P., Liu M., Liao X. Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies. Mol Biol Rep 2013; 40 (1): 497-506.

[18]	Holick M.F. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281.

[19]	Huang J., Ushiyama T., Inoue K., Kawasaki T., Hukuda S. Vitamin D receptor gene polymorphisms and osteoarthritis of the hand, hip, and knee: a case-control study in Japan. Rheumatology 2000; 39: 79-84.

[20]	Jakubowska-Pietkiewicz E., Mlynarski W., Klich I., Fendler W., Chlebna-Sokol D. Vitamin D receptor gene variability as a factor influencing bone mineral density in pediatric patients. Mol Biol Rep 2012; 39(5): 6243-6250.

[21]	Jia F., Sun R.F., Li Q.H., Wang D.X., Zhao F., Li J.M., Pu Q., Zhang Z.Z., Jin Y., Liu B.L., Xiong Y. Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies. Genet Test Mol Biomarkers 2013; 17 (1): 30-44.

[22]	Kostner K., Denzer N., Muller C.S., Klein R., Tilgen W., Reichrath J. The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res 2009; 29(9): 3511-3536.

[23]	Kremer R., Campbell P.P., Reinhardt T., Gilsanz V. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab 2009; 94 (1): 67-73.

[24]	Lorentzon M., Lorentzon R., Nordstrom P. Vitamin D receptor gene polymorphism is associated with birth height, growth to adolescence, and adult stature in healthy Caucasian men: a cross-sectional and longitudinal study. J Clin Endocrinol Metab 2000; 85 (4): 1666-1670.

[25]	Raimondi S., Johansson H., Maisonneuve P., Gandini S. Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis 2009; 30 (7): 1170-1180.

[26]	Schuch N.J., Garcia V.C., Vivolo S.R.G.F., Martini L.A. Relationship between Vitamin D Receptor gene polymorphisms and the components of metabolic syndrome. Nutrition Journal 2013; 12: 96, аvailable at: http:// www.nutritionj.com/content/12/1/96.

[27]

Selvaraj P., Chandra G., Jawahar M.S., Rani M.V., Rajeshwari D.N., Narayanan P.R. Regulatory role of vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms on macrophage phagocytosis and lymphoproliferative response to Mycobacterium tuberculosis antigen in pulmonary tuberculosis. J Clin Immunol 2004; 24: 523-532.

[28]	Suarez F., Zeghoud F., Rossignol C., Walrant O., Garabedian M. Association between vitamin D receptor gene polymorphism and sex-dependent growth during the first two years of life. J Clin Endocr Metabol 1997; 82 (9): 2966-2970.

[29]	Sun J.L., Meng H.X., Cao C.F., Tachi Y., Shinohara M., Ueda M., Imai H., Ohura K. Relationship between vitamin D receptor gene polymorphism and periodontitis. J Periodont Res 2002; 37: 263-267.

[30]	Swapna N., Mohana Vamsi U., Usha G., Padma T. Risk conferred by FokI polymorphism of vitamin D receptor (VDR) gene for essential hypertension. Ind J Hum Genet 2011; 17 (3): 201-206.

[31]	Tao C., Yu T., Garnett S., Briody J., Knight J., Woodhead H., Cowell C.T. Vitamin D receptor alleles predict growth and bone density in girls. Arch Dis Child 1998; 79: 488-494.

[32]	Touvier M., Chan D.S.M., Lau R., Aune D., Vieira R., Greenwood D.C., Kampman E., Riboli E., Hercberg S., Norat T. Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidem. Biomark Prevent 2011; 20 (5): 1003-1016.

[33]	Uitterlinden A.G., Fang Y., Bergink A.P., van Meurs J.B.J., van Leeuwen H.P.T. M., Pols H.A.P. The role of vitamin D receptor gene polymorphisms in bone biology. Mol Cel Endocrinol 2002; 197 (1-2): 15-21.

[34]	Uitterlinden A.G., Fang Y., van Meurs J.B.J., Pols H.A.P., van Leeuwen J.P.T.M. Genetics and biology of vitamin D receptor polymorphisms: Review. Gene 2004; 338: 143-156.

[35]	Zerwekh J.E. Blood biomarkers of vitamin D status. Am J Clin Nutr 2008; 87: 1087S-1091S.

[36]	Zhu Z.H., Jin X.Z., Zhang W., Chen M., Ye D.Q., Zhai Y., Dong F.L., Shen C.L., Ding C. Associations between vitamin D receptor gene polymorphisms and osteoarthritis: an updated meta-analysis. Rheumatology (Oxford) 2014; 53(6): 998-1008.

[37]	Zintzaras E., Rodopoulou P., Koukoulis G.N. BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: a meta-analysis. Dis Markers 2006; 22: 317-326.