COGNITIVE POTENTIAL ACTIVATION IN EXPERIMENTAL ANIMALS ENTERALLY INTRODUCED HISTONDEACETYLASE INHIBITOR PRECURSORS

Abstract

Aim. To study the effect of short-chain fatty acids (SCFA), as natural histondeacetylase inhibitors, on cognitive function of experimental animals. Materials and methods. Cognitive peculiarities of 32 white outbred male mice, aged 15 to 16 weeks, were studied. Mice were divided into 4 groups depending on their diet and tested in T-shaped labyrinth. Results. In the control group, after a thrice-repeated training in a T-shaped labyrinth, the formation of reflex was revealed in 2 out of 9 experimental animals ( p > 0,05). In the group of animals, who in addition to usual nutrition received fructooligosaccharides (inulin), reflex was obtained in 2 out of 7 experimental animals ( p > 0,05). In the group of animals, who additionally took wheat bran, reflex was formed in 3 animals out of 8 ( p > 0,05). In the animals of group 4, who additional received a natural complex containing SCFA and fermentable dietary fibers (BAS “Reckicen-RD”), this reflex was formed in 6 animals out of 8 ( p < 0,05). Conclusions. It was stated that when using a natural complex of FDF and SCFA, the experimental animals’ learning capability in the T-shaped labyrinth statistically significantly increased versus the control group.

Keywords

Reflex / memory / T-shaped labyrinth / short-chain fatty acids / histondeacetylase inhibitors

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RIGHTS & PERMISSIONS

Kuznetsov S.B., Kuznetsov V.F., Obernebesova T.P.