PATHOGENETIC AND CLINICAL PECULIARITIES OF DISSEMINATED SCLEROSIS

T V Baidina; E M Kuklina; T N Trushnikova; Yu A Pichkaleva; N V Sursyakova; I Yu Danchenko; E L Medvedeva; A V Foteeva

doi:10.17816/pmj33417-22

Perm Medical Journal ›› 2016, Vol. 33 ›› Issue (4) :17 -22. DOI: 10.17816/pmj33417-22

Articles

research-article

PATHOGENETIC AND CLINICAL PECULIARITIES OF DISSEMINATED SCLEROSIS

Author information +

History +

PDF

Abstract

Aim. The aim of the study was to investigate the gender structure, peculiarities of fatigue syndrome and depressive disorders in patients with disseminated sclerosis (DS); to determine the cytokine status and neurotrophic mechanism, serotoninergic, semaphorin Sema4 (CD100) statuses of the above mentioned disease. Materials and methods. Patients with a reliable diagnosis of disseminated sclerosis were examined according to McDonald 2010 criteria with remittent type of disease course. Clinical method, psychometric testing, immune-enzyme analysis, immunological methods were used. Results. In process of disseminated sclerosis, patients' gender shifts to femininity. Fatigue and emotional disorders are inseparable symptoms of this disease. Neurochemistry of disseminated sclerosis is characterized by serotoninergic insufficiency and deficiency of neurotrophic mechanisms; inflammatory process does not stop in the phase of clinical remission, but semaphorin system is participating in formation of immunopathological reactions. Conclusions. Clinical and pathogenetic characteristics of disseminated sclerosis are supplemented by new data, which can be the targets of new therapeutic strategies.

Keywords

Gender / fatigue / disseminated sclerosis / cytokines / neurotrophic factor / serotonin / semaphorin

Cite this article

Download citation ▾

T V Baidina, E M Kuklina, T N Trushnikova, Yu A Pichkaleva, N V Sursyakova, I Yu Danchenko, E L Medvedeva, A V Foteeva. PATHOGENETIC AND CLINICAL PECULIARITIES OF DISSEMINATED SCLEROSIS. Perm Medical Journal, 2016, 33(4): 17-22 DOI:10.17816/pmj33417-22

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Акинцева Ю.В., Трушникова Т.Н., Байдина Т.В. Влияние синдрома усталости на качество жизни больных с рассеянным склерозом. Неврологический вестник. Журнал им. В.М. Бехтерева 2010; 42 (1): 132.

[2]	Байдина Т.В., Акинцева Ю.В., Трушникова Т.Н. Тромбоцитарный серотонин при рассеянном склерозе и его связь с синдромом усталости. Нейрохимия 2013; 30 (3): 254.

[3]	Куклина Е.М., Байдина Т.В., Данченко И.Ю., Некрасова И.В. Семафорин Sema4D в иммунной системе при рассеянном склерозе. Бюллетень экспериментальной биологии и медицины 2014; 157 (2): 198-201.

[4]	Трушникова Т.Н., Медведева Е.Л., Байдина Т.В., Данилова М.А. Мозговой и цилиарный нейротрофические факторы у больных рассеянным склерозом. Журнал неврологии и психиатрии им. C.C. Корсакова 2014; 114 (10-2): 33-36.

[5]	Трушникова Т.Н., Байдина Т.В., Данченко И.Ю., Куклина Е.М., Некрасова И.В. Экспрессия семафорина CD100 на лимфоцитах периферической крови пациентов с ремитирующим течением рассеянного склероза. Журнал неврологии и психиатрии им. C.C. Корсакова 2013; 113 (10-2): 47-51.