ASSOCIATION OF SALIVARY CORTISOL LEVEL WITH ADIPOPEXIS IN HEALTHY YOUNG ADULTS

Abstract

Aim. The aim of the study was to analyze the association of somatic indices with salivary cortisol (SC) level in healthy young adults. Materials and methods. Examination of 154 healthy students aged 20-23 years (102 women, 52 men) was conducted. Anthropometric study included the measurement of the body length and mass, waist and femur circumferences. Salivary cortisol content was determined using immunoenzyme method. Results. Salivary cortisol level in the examined persons (4,87 nmol/l) was reduced, but did not exceed the standard variation limits. No significant associations of SC content with the body length and mass and mass-height indices were revealed. The waist circumference to femur circumference ratio correlated with salivary cortisol level in men ( Rsp = -0,29; p = 0,036), but not in women. Conclusions. The results agree with the data of publications and confirm the hypothesis that cortisol production is associated with healthy human somatic characteristics.

Keywords

Cortisol / height / body mass / waist circumference / body mass index

References

[1] Бунак В.В. Антропометрия. М.: Учпедгиз 1941; 367.

[2] Бутрова С.А. Метаболический синдром: патогенез, клиника, диагностика, подходы к лечению. Русский медицинский журнал 2002; 2: 46-52.

[3] Козлов А.И., Козлова М.А. Кортизол как маркер стресса. Физиология человека 2014; 40 (2): 123-136.

[4] Негашева М.А., Михайленко В.П., Корнилова В.М. Разработка нормативов физического развития юношей и девушек 17-18 лет. Педиатрия: журнал им. Сперанского 2007; 86 (1): 68-73.

[5] Негашева М.А., Мишкова Т.А. Антропометрические параметры и адаптационные возможности студенческой молодёжи к началу XXI века. Российский педиатрический журнал 2005; 5: 12-16.

[6] Abraham S.B., Rubino D., Sinaii N., Ramsey S., Nieman L.K. Cortisol, obesity and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature. Obesity (Silver Spring) 2013; 21 (1): E105-E117.

[7] Bose M., Olivan B., Laferrere B. Stress and obesity: the role of the hypothalamic-pituitary - adrenal axis in metabolic disease. Curr Opin Endocrinol Diabetes Obes 2009; 16 (5): 340-346.

[8] Brune M., Hochberg Z. Secular trends in new childhood epidemics: insights from evolu-tionary medicine. BMC Medicine 2013; 11: 226.

[9] Duclos M., Marquez Pereira P., Barat P., Gatta B., Roger P. Increased cortisol bioavaila-bility, abdominal obesity, and the metabolic syndrome in obese women. Obes Res 2005; 13: 1157-1166.

[10] Eckel R.H. Obesity: Mechanism and clinical management. Philadelphia: Lippincott Williams & Wilkins 2003; 595.

[11] Epel E., McEwen B., Seeman T., Mat-thews K., Castellazzo G., Brownell K. D., Bell J., Ickovics J.R. Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med 2000; 62 (5): 623-632.

[12] Holmang A. Metabolic effects of steroid hormones in skeletal muscles. BAM 1993; 3 (2): 133-141.

[13] Kirschbaum C., Hellhammer D.H. Salivary cortisol. Encyclopedia of Stress. Ed. G. Fink. San Diego: Academic Press 2000; 3: 379-384.

[14] Ljung T., Holm G., Friberg P., Anders-son B., Bengtsson B., Svensson J., Dallman M., McEwen B., Bjorntorp P. The activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in relation to waist/hip circumference ratio in men. Obes Res 2000; 8: 487-495.

[15] Moyer A.E., Rodin J., Grilo C.M., Cummings N., Larson L.M., Rebuffe-Scrive M. Stress-induced cortisol response and fat distribu-tion in women. Obes Res 1994; 2: 255-262.

[16] Neovius M., Linne Y., Rossner S. BMI, waist-circumference and waist-hip-ratio as diagnostic tests for fatness in adolescents. Int J Obes (Lond) 2005; 29 (2): 163-169.

[17] Power C., Leah L., Hertzman C. Associa-tions of early growth and adult adiposity with patterns of salivary cortisol in adulthood. J Clin Endocrinol Metab 2006; 91 (11): 4264-4270.

[18] Rivera M.P., Svec F. Is cortisol involved in upper-body obesity? Med Hypotheses 1989; 30 (2): 95-100.

[19] Rosmond R., Holm G., Bjorntorp P. Food-induced cortisol secretion in relation to anthropometric, metabolic and haemodynamic variables in men. Int J Obesity Relat Metab Disord 2000; 24 (4): 416-422.

[20] Schorr M., Lawson E.A., Dichtel L.E., Klibanski A., Miller K.K. Cortisol measures across the weight spectrum. JCEM 2015; 100 (9), available at: http://dx.doi.org/10.1210/JC.2015-2078

[21] Stolk R.P., Lamberts S.W.J., de Jong F.H., Pols H.A.P., Grobbee D.E. Gender differences in the associations between cortisol and insulin in healthy subjects. J Endocrinol 1996; 149: 313-318.

RIGHTS & PERMISSIONS

Kozlov A.I., Vershubskaya G.G., Manukyan A.S., Negasheva M.A.