PECULIARITIES OF DISTRIBUTION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS IN CHILDREN OF DIFFERENT AGE WITH ATOPIC DERMATITIS
Ya Yu Illek , G A Zaitseva , E Yu Suslova , A V Galanina , E Yu Tarasova , N P Leushina , I Yu Mischenko
Perm Medical Journal ›› 2015, Vol. 32 ›› Issue (3) : 82 -85.
PECULIARITIES OF DISTRIBUTION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS IN CHILDREN OF DIFFERENT AGE WITH ATOPIC DERMATITIS
Aim. To study the peculiar features of distribution of HLA-complex antigens in children of early age, preschool, junior school age and adolescents suffering from atopic dermatitis. Materials and methods. The study involved 128 children aged 8 months to 15 years suffering from disseminated moderately severe and severe atopic dermatitis, who were divided into 3 age groups and examined. Group I ( n = 76) included children of early age (patients’ age 8 months to 3 years), group 2 ( n = 32) - children of preschool and junior school age (patients’ age 5-10 years). group 3 ( n = 20) - adolescents (patients’ age 12-15 years). In patients with atopic dermatitis, serological typing by HLA antigens of class I and molecular typing of HLA-genes - class II HLA antigens was performed. Results. In children of early age, preschool, junior school age and adolescents, suffering from atopic dermatitis, associative relation with different major histocompatibility complex antigens was revealed that permitted to single out immunogenetic markers of this disease for patients of different age groups.
Children / atopic dermatitis / major histocompatibility complex antigens
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Illek Y.Y., Zaitseva G.A., Suslova E.Y., Galanina A.V., Tarasova E.Y., Leushina N.P., Mischenko I.Y.
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