PATHOLOGICAL CLIMACTERIC COURSE PREDICTORS

Abstract

Aim. To determine the predictors of pathological climacteric course. Materials and methods. 122 women in the early menopause were examined: group 1 - 62 women with pathological climacteric course (mean age 51,4±1,1years); group 2 - 60 women with physiological climacteric course (mean age 51±1,5 years). Menopausal index (in scores) proposed by Kupperman et al. (1959) and modified by E. V. Uvarova served as a group division criterion. The groups were comparable by their social status. The exclusion criteria were serious extragenital pathology, severe degree of pathological menopause, oncological diseases, smoking and alcohol abuse. Results. Analysis of the level of education and character of professional activity, harmful factors and habits in women with pathological and physiological menopause resulted in no reliable differences revealed. Family status was different in the studied groups: most women with pathological climacteric were unmarried: divorced, widows, never married; women with physiological climacteric were predominantly married. Peculiar features of obstetric anamnesis did not influence the character of climacteric course. Reliable differences between the groups concerning ovarian pathology and menstrual disorders were found: both signs more often occurred in women with pathological climacteric course. In women with physiological and pathological course of crimax, significant differences in relation to GIT diseases and thyroid pathology were detected. In case of pathological climax, GIT diseases were revealed 1,5 times more often ( p <0,05), reduction in thyroid function - 3,5 times more often. Pathological climax was characterized predominantly by excess body mass (BMI 25-30), physiological climax - by normal body mass (BMI 20-25). Conclusions. Unmarried status, menstrual disorders, ovarian pathology in anamnesis, GIT diseases, latent and clinical hypothyroidism, excess body mass are significant for formation of climacteric and are predictors of its pathological course. Educational level, peculiarities of professional activity, occupational hazard, bad habits, number of pregnancies, hormonal contraception do not influence the character of climacteric course.

Keywords

Predictors / physiological climacteric course / pathological climacteric course

References

[1] Вихляева Е. М. Постменопаузальная терапия. М.: МЕДпресс-информ 2008; 42-45.

[2] Вихляева Е. М., Железнов Б. И., Запорожан В. Н., Кузнецова М. Н., Фанченко Н. Д., Щедрина Р. Н. Руководство по эндокринной гинекологии. М.: МИА 2006; 765.

[3] Звычайный М. А., Воронцова А. В., Енотова Е. М., Антропова М. Ц., Митяшина А. М. Концепция antiageing терапии у женщин с дефицитом половых стероидов. Материалы VII российского форума «Мать и дитя». М. 2005; 383.

[4] Ильина Л. М. Изменение внешности с возрастом (возможности заместительной гормональной терапии). Гинекология 2003; 5 (3): 108-112.

[5] Сметник В. П. Неоперативная гинекология. М.: МИА 2005; 629.

[6] Сметник В. П., Кулаков В. И. Руководство по климактерию. М.: МИА 2001; 685.

[7] Sator P. G., Sator M. O., Schmidt J. B. A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women. Climacteric 2007; 10: 320-334.

RIGHTS & PERMISSIONS

Sandakova E.A., Elkin V.D., Kobernik M.Y.