CLINICAL SIGNIFICANCE OF EXPIRED AIR NITRIC OXIDE FRACTIONAL DETERMINATION AS INSTRUMENT OF DIAGNOSIS AND THERAPEUTIC EFFICIENCY ASSESSMENT OF PEDIATRIC CHRONIC RESPIRATORY DISEASES

S E Tsyplenkova; Yu L Mizernitsky

doi:10.17816/pmj31256-61

Perm Medical Journal ›› 2014, Vol. 31 ›› Issue (2) :56 -61. DOI: 10.17816/pmj31256-61

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CLINICAL SIGNIFICANCE OF EXPIRED AIR NITRIC OXIDE FRACTIONAL DETERMINATION AS INSTRUMENT OF DIAGNOSIS AND THERAPEUTIC EFFICIENCY ASSESSMENT OF PEDIATRIC CHRONIC RESPIRATORY DISEASES

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Abstract

Aim. To analyze new possibilities of fractional determination of the expired air nitric oxide. Materials and methods. 120 children aged 2-18, ill with bronchial asthma, primary ciliary dyskinesia (PCD) and other diseases were examined. To carry out fractional determination of the expired air nitric oxide, Analyzer CLD88 (ECO MEDICS®, Switzerland) was used. Estimation of the results of alveolar test (subsequent thrice-repeated determination of Fe NO with the expiratory rate of 30, 100 and 300 l/min) was performed by the following parameters: Ca NO (alveolar NO concentration); Caw NO (NO concentration in the upper airway tissues); Daw NO (NO duffusion rate); Jaw NO (NO flow from the upper airway tissues); Fe NO50 (extrapolated Fe NO value with the expiratory rate of 50 ml/s). Results. Caw NO level moderately correlated (r=0,58) with the nasal nitric oxide level and ranged from 5,7 ppb (in PCD patients) to 473,5 ppb (in a child with severe BA associated with exacerbated allergic rhinitis). Higher correlation degree was revealed between Jaw NO level (166,6÷8815,8 pl/s) and Fe NO and Fe NO50 level ( r =0,82 and r =0,78, respectively). Conclusion. Differentially diagnostic significance of the determined indices in bronchial asthma and primary ciliary dyskinesia was shown.

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Children / expired air nitric oxide fractional determination / bronchial asthma / primary ciliary dyskinesia / functional diagnosis

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S E Tsyplenkova, Yu L Mizernitsky. CLINICAL SIGNIFICANCE OF EXPIRED AIR NITRIC OXIDE FRACTIONAL DETERMINATION AS INSTRUMENT OF DIAGNOSIS AND THERAPEUTIC EFFICIENCY ASSESSMENT OF PEDIATRIC CHRONIC RESPIRATORY DISEASES. Perm Medical Journal, 2014, 31(2): 56-61 DOI:10.17816/pmj31256-61

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