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Journal of Translational Neuroscience    2016, Vol. 1 Issue (1) : 32-36
Translation of basic science into clinical medicine in management for neurogenic bladder
Limin Liao1,2,3*,Guoqing Chen1,2,3, Fan Zhang1,2,3
1.Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China;
2.Department of Urology, China Rehabilitation Research Center, Beijing 100068, China;3.Department of Urology, Capital Medical University, Beijing 100069, China
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Abstract Neurogenic bladder (NB) dysfunction caused by spinal cord injury (SCI) or diseases of the central nervous system or peripheral nerves is a major medical and social problem. Traditional treatments to NB include medication, injection of Botulinum toxin A into the detrusor, neuromodulation and surgery. There are also emerging approaches, such as tissue engineering, stem cell transplantation and gene therapy. In recent years, we have carried out explorations in both therapeutic areas and tried to translate basic research into clinical practice. This paper reviews our work in this regard, and provides references for future research.
Keywords neurogenic bladder (NB)      medication      urinary tract reconstruction      neuromodulation      stem cell transplantion      gene therapy     
Corresponding Author(s): *Limin Liao, E-mail:   
Issue Date: 14 October 2016
 Cite this article:   
Limin Liao,Guoqing Chen,Fan Zhang. Translation of basic science into clinical medicine in management for neurogenic bladder[J]. Journal of Translational Neuroscience, 2016, 1(1): 32-36.
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Articles by authors
Limin Liao
Guoqing Chen
Fan Zhang
[1] Chen G, Liao L, Li Y. The possible role of percutaneous tibial nerve stimulation using adhesive skin surface electrodes in patients with neurogenic detrusor overactivity secondary to spinal cord injury. Int Urol Nephrol, 2015, 47(3): 451-455.
[2] Chen G, Liao L. Injections of botulinum toxin A into the detrusor to treat neurogenic detrusor overactivity secondary to spinal cord injury.Int Urol Nephrol, 2011, 43(3): 655-662.
[3] Jia C, Liao LM, Chen G, et al. Detrusor botulinum toxin A injection significantly decreased urinary tract infection in patients with traumatic spinal cord injury.Spinal Cord, 2013, 51(6): 487-490.
[4] Zhang F, Liao L, Ju Y, et al. Neurochemical plasticity of nitric oxide synthase isoforms in neurogenic detrusor overactivity after spinal cord injury, 2011, 36(10): 1903-1909.
[5] Biers SM, Venn SN, Greenwell TJ. The past, present and future of augmentation cystoplasty. BJU Int, 2012, 109(9): 1280-1293.
[6] Liao L, Zhang F, Chen G. New grading system for upper urinary tract dilation using magnetic resonance urography in patients with neurogenic bladder.BMC Urol, 2014, 14: 38.
[7] Liao L, Zhang F, Chen G.Midterm outcomes of protection for upper urinary tract function by augmentation enterocystoplasty in patients with neurogenic bladder.Int Urol Nephrol, 2014, 46(11): 2117-2125.
[8] Liao L.A new comprehensive classification system for both lower and upper urinary tract dysfunction in patients with neurogenic bladder. Urol Int, 2015, 94(2): 244-248.
[9] Wang Y, Liao L. Histologic and functional outcomes of small intestine submucosa-regenerated bladder tissue.BMC Urol, 2014, 14: 69.
[10] Zhang F, Liao L. Tissue engineered cystoplasty augmentation for treatment of neurogenic bladder using small intestinal submucosa: an exploratory study. J Urol, 2014, 192(2): 544-550.
[11] Chen G, Liao L, Dong Q, et al. The inhibitory effects of pudendal nerve stimulation on bladder overactivity in spinal cord injury dogs: is early stimulation necessary? Neuromodulation, 2012, 15(3): 232-237.
[12] Li P, Liao L, Chen G, et al. Early low-frequency stimulation of the pudendal nerve can inhibit detrusor overactivity and delay progress of bladder fibrosis in dogs with spinal cord injuries. Spinal Cord, 2013, 51(9): 668-672.
[13] Chen G, Larson JA, Ogagan PD, et al. Post-stimulation inhibitory effect on reflex bladder activity induced by activation of somatic afferent nerves in the foot.J Urol, 2012, 187(1): 338-343.
[14] Zhang F, Mally AD, Ogagan PD, et al. Inhibition of bladder overactivity by a combination of tibial neuromodulation and tramadol treatment in cats. Am J Physiol Renal Physiol, 2012, 302(12): F1576-1582.
[15] Hu Y, Liao LM, Ju YH, et al. Intravenously transplanted bone marrow stromal cells promote recovery of lower urinary tract function in rats with complete spinal cord injury. Spinal Cord, 2012, 50(3): 202-207.
[16] Jia C, Yoshimura N, Liao L.Herpes simplex virus vector-mediated gene transfer of kynurenine aminotransferase improves detrusor overactivity in spinal cord-injured rats. Gene Ther, 2014, 21(5): 484-489.
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